1. GPCR/G Protein
    Neuronal Signaling
  2. Adrenergic Receptor
  3. Pronethalol hydrochloride

Pronethalol hydrochloride (Synonyms: (±)-Pronethalo hydrochloride)

目录号: HY-B1238A
产品使用指南

Pronethalol ((±)-Pronethalo) 是一种非选择性的 β-肾上腺素 (β-adrenergic) 拮抗剂。 Pronethalol 是有效的 Sox2 表达抑制剂。Pronethalol 可预防和逆转洋地黄引起的室性心律失常,也可以限制脑动静脉畸形 (AVMs)。

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Pronethalol hydrochloride Chemical Structure

Pronethalol hydrochloride Chemical Structure

CAS No. : 51-02-5

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Description

Pronethalol ((±)-Pronethalo) is a non-selective β-adrenergic antagonist. Pronethalol is a potent inhibitor of Sox2 expression. Pronethalol protects against and to reverse Digitalis-induced ventricular arrhythmias, and limits the cerebral arteriovenous malformation (AVMs)[1][2].

In Vitro

Pronethalol (2, 10, 20 μM) represses EGFP expression in a dose- and time-dependent manner in ReNcell VM cells. Pronethalol (10 μM; 2 days) reduces Sox2 expression to less than 10% after 2 days of treatment[2].

In Vivo

Pronethalol (0.15 mg/g; daily; for 14 days) stabilizes endothelial differentiation, lumen formation and improves cerebral arteriovenous malformation (AVMs) in Mgp–/– mice[2].

Molecular Weight

265.78

Formula

C₁₅H₂₀ClNO

CAS No.

51-02-5

中文名称

盐酸普罗纳赛洛;盐酸丙萘洛尔

SMILES

OC(CNC(C)C)C1=CC=C2C=CC=CC2=C1.Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

Pronethalol(±)-PronethaloAdrenergic ReceptorBeta ReceptorSox2expressionDigitalisventriculararrhythmiascerebralarteriovenousmalformationAVMsEGFPendothelialdifferentiationlumenformationInhibitorinhibitorinhibit

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Pronethalol hydrochloride
目录号:
HY-B1238A
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