1. Antibody-drug Conjugate/ADC Related
    PROTAC
  2. ADC Linker
    PROTAC Linker
  3. Propargyl-PEG2-NHBoc

Propargyl-PEG2-NHBoc 

目录号: HY-118808
产品使用指南

Propargyl-PEG2-NHBoc 是一种可降解 (cleavable) 的 ADC 连接桥,用于抗体药物结合物 (ADCs) 的合成。Propargyl-PEG2-NHBoc 是一种 PROTAC 连接桥,属于 PEG 类。Propargyl-PEG2-NHBoc 可用于合成一系列 PROTAC 分子。

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Propargyl-PEG2-NHBoc Chemical Structure

Propargyl-PEG2-NHBoc Chemical Structure

CAS No. : 869310-84-9

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Description

Propargyl-PEG2-NHBoc is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). Propargyl-PEG2-NHBoc is a PEG-based PROTAC linker can be used in the synthesis of PROTACs[1].

IC50 & Target

Cleavable

 

PEGs

 

Alkyl/ether

 

In Vitro

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.

Molecular Weight

243.30

Formula

C₁₂H₂₁NO₄

CAS No.

869310-84-9

SMILES

O=C(NCCOCCOCC#C)OC(C)(C)C

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

References
  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

Propargyl-PEG2-NHBocADC LinkerPROTAC LinkerAntibody-drug conjugates linkercleavableADCantibody-drugconjugatesPEGPROTAClinkerE3ubiquitinligaseproteinInhibitorinhibitorinhibit

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产品名称:
Propargyl-PEG2-NHBoc
目录号:
HY-118808
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