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Pyridine-3-sulfonic acid  (Synonyms: Pyridine-3-sulphonic acid)

目录号: HY-W015467 纯度: 98.0%
COA 产品使用指南 技术支持

Pyridine-3-sulfonic acid (Pyridine-3-sulphonic acid) 是一种口服有效的 Nicotinic acid (HY-B0143) 的结构类似物。Pyridine-3-sulfonic acid 可显著降低大鼠肝脏胆固醇合成，但无降胆固醇活性。Pyridine-3-sulfonic acid 不干预 Nicotinic acid 的代谢。

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Pyridine-3-sulfonic acid

Pyridine-3-sulfonic acid Chemical Structure

CAS No. : 636-73-7

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Pyridine-3-sulfonic acid 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Pyridine-3-sulfonic acid (Pyridine-3-sulphonic acid) is an orally active structural analog of Nicotine acid (HY-B0143). Pyridine-3-sulfonic acid significantly reduces hepatic cholesterol synthesis in rats but lacks cholesterol-lowering activity. Pyridine-3-sulfonic acid does not interfere with the metabolism of Nicotine acid[1][2].

体内研究
(In Vivo)

Pyridine-3-sulfonic acid (1%，每日 100 克饮食中加入 1 克，随餐口服，连续 21 天) 可显著降低大鼠肝脏胆固醇合成[1]。
Pyridine-3-sulfonic acid (0.5-2 克，随餐口服) 不会干扰正常犬或缺乏烟酸的犬体内烟酰胺与辅酶 I/II 的结合或代谢[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Normal diet and high cholesterol diet model established in male Wistar rats (150-160 g)[1]
Dosage: 1%, 1 g/100 g daily diet
Administration: Oral administration (p.o.) with food, for 21 days
Result: Did not significantly alter serum cholesterol levels in the normal diet group.
Did not show cholesterol-lowering activity in the high-cholesterol diet group.
Significantly reduced liver cholesterol synthesis.
分子量

159.17

Formula

C5H5NO3S
CAS 号
性状

固体

颜色

White to off-white

中文名称

吡啶-3-磺酸
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
纯度 & 产品资料

纯度: ≥98.0%

COA (292 KB) HNMR (118 KB)

产品使用指南 (1538 KB)
参考文献

Pyridine-3-sulfonic acid 相关分类

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Keywords:

Pyridine-3-sulfonic acid636-73-7Pyridine-3-sulphonic acid吡啶-3-磺酸OthersNicotinic acidWistar ratsAntimetabolitesHypocholesterolemic effectInhibitorinhibitorinhibit

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