2. GPCR/G Protein Neuronal Signaling Metabolic Enzyme/Protease
  3. Adrenergic Receptor NADPH Oxidase
  4. (Rac)-Nebivolol

(Rac)-Nebivolol  (Synonyms: (Rac)-奈必洛尔; (Rac)-R 065824)

目录号: HY-B0203B
产品使用指南

摩尔计算器

(Rac)-Nebivolol ((Rac)-R 065824) 是 Nebivolol 的外消旋异构体。Nebivolol 是一种具有选择性的β1 肾上腺素能受体拮抗剂，IC50 为 0.8 nM。在乙醇引起心脏毒性的早期阶段，Nebivolol 能预防 Nox2/NADPH 氧化酶上调和脂质过氧化。具有血管舒张活性。

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(Rac)-Nebivolol Chemical Structure

(Rac)-Nebivolol Chemical Structure

CAS No. : 99200-09-6

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规格 价格 是否有货
1 mg ￥1600
询问价格 & 货期
5 mg ￥3500
询问价格 & 货期
10 mg ￥5600
询问价格 & 货期

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Customer Review

Other Forms of (Rac)-Nebivolol:

(Rac)-Nebivolol 相关抗体

Top Publications Citing Use of Products

查看 Adrenergic Receptor 亚型特异性产品:

查看所有亚型
α adrenergic receptor β adrenergic receptor

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

(Rac)-Nebivolol ((Rac)-R 065824) is a racemic isomer of Nebivolol. Nebivolol is a selective β1-adrenergic receptor antagonist with an IC50 value of 0.8 nM. Nebivolol can prevent up-regulation of Nox2/NADPH oxidase and lipoperoxidation in the early stages of ethanol-induced cardiac toxicity. Vasodilatory activity[1][2].

IC50 & Target

NOX2

 

体内研究
(In Vivo)

Nebivolol (10 mg/kg; daily for 7 days) markedly improves endothelial dysfunction and increases P-VASP levels; prevents NOS III uncoupling; significantly inhibit NADPH oxidase in Angiotensin II-treated rats[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

405.44

Formula

C22H25F2NO4
CAS 号
中文名称

(Rac)-奈必洛尔
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

(Rac)-Nebivolol 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

(Rac)-Nebivolol99200-09-6(Rac)-R 065824(Rac)-奈必洛尔Adrenergic ReceptorNADPH OxidaseBeta ReceptorNOXracemic isomervasodilatorycardiac toxicityNox2/NADPH oxidaselipoperoxidationAngiotensin IIInhibitorinhibitorinhibit

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