2. Membrane Transporter/Ion Channel Neuronal Signaling
  3. nAChR
  4. (±)-Anatoxin A fumarate

(±)-Anatoxin A fumarate 

目录号: HY-N2326 纯度: ≥98.0%
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(±)-Anatoxin A fumarate 是从淡水蓝藻菌中分离得到的天然生物碱。(±)-Anatoxin A fumarate 是一种强效的烟碱受体 (nicotinic receptor) 激动剂，结合大鼠的脑膜的 α4β2 和 α7 型受体的 Ki 值分别为 1.25 nM 和 1.84 μM。(±)-Anatoxin A fumarate 刺激大鼠纹状体突触体释放多巴胺的 EC50 值为 134 nM。

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(±)-Anatoxin A fumarate Chemical Structure

(±)-Anatoxin A fumarate Chemical Structure

CAS No. : 1219922-30-1

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1 mg ￥8900
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(±)-Anatoxin A fumarate 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

(±)-Anatoxin A fumarate is a natural alkaloid isolated from freshwater cyanobacterium.(±)-Anatoxin A fumarate is a potent nicotinic receptor agonist and exhibits Ki values of 1.25 nM and 1.84 μM for binding to putative α4β2-type nAChR and α7-type nAChR in rat brain membranes, respectively. (±)-Anatoxin A fumarate stimulates [3H]-dopamine release from rat striatal synaptosomes (EC50=134 nM)[1].

IC50 & Target

Ki: 1.25 nM ( α4β2 receptor)
Ki: 1.84 μM ( α7 receptor)[1]
分子量

281.30

Formula

C14H19NO5
CAS 号
性状

油状物

颜色

Light yellow to yellow

运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

纯度 & 产品资料

纯度: ≥98.0%

COA (271 KB)

产品使用指南 (1538 KB)
参考文献

(±)-Anatoxin A fumarate 相关分类

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  • Do most proteins show cross-species activity?

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Keywords:

(±)-Anatoxin A1219922-30-1nAChRNicotinic acetylcholine receptorscyanobacteriumα4β2-typeα7-typebrain membranestriatalsynaptosomeInhibitorinhibitorinhibit

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