1. Vitamin D Related/Nuclear Receptor
  2. Estrogen Receptor/ERR
  3. Raloxifene 4'-glucuronide-d4 lithium

Raloxifene 4'-glucuronide-d4 lithium 

目录号: HY-135582S1
产品使用指南

Raloxifene 4'-glucuronide-d4 (lithium) 是 Raloxifene 4'-glucuronide 氘代物。Raloxifene 4'-glucuronide 是 Raloxifene 的主要代谢产物。Raloxifene 4'-glucuronide 的形成主要由 UGT1A10 和 UGT1A8 介导,以 IC50 为 370 μM 与 estrogen receptor 结合。Raloxifene 是选择性雌激素受体调节剂。 Raloxifene 在纳摩尔浓度激活 TGFβ3 启动子为完全激动剂,并抑制含雌激素反应元件的卵黄蛋白原启动子的表达。

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Raloxifene 4'-glucuronide-d<sub>4</sub> lithium Chemical Structure

Raloxifene 4'-glucuronide-d4 lithium Chemical Structure

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查看 Estrogen Receptor/ERR 亚型特异性产品:

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Raloxifene 4'-glucuronide-d4 (lithium) is deuterium labeled Raloxifene 4'-glucuronide. Raloxifene 4'-glucuronide is a primary metabolite of Raloxifene. Raloxifene 4'-glucuronide formation is mediated mostly by UGT1A10 and UGT1A8. Raloxifene 4'-glucuronide binds to estrogen receptor with an IC50 of 370 μM. [1][2]. Raloxifene is a selective estrogen receptor modulator. Raloxifene activates TGFβ3 promoter as a full agonist at nanomolar concentrations, and inhibits the estrogen response element-containing vitellogenin promoter expression[3].

体外研究
(In Vitro)

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

659.67

Formula

C34H30D4LiNO10S

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

纯度 & 产品资料
参考文献

Raloxifene 4'-glucuronide-d4 lithium 相关分类

  • 摩尔计算器

  • 稀释计算器

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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产品名称:
Raloxifene 4'-glucuronide-d4 lithium
目录号:
HY-135582S1
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