2. Immunology/Inflammation
  3. CD19 CD28
  4. RG-6333

RG-6333  (Synonyms: RO7443904)

目录号: HY-P991176
技术支持

RG-6333 是一种靶向 CD19 和 CD28 的双特异性激动剂。RG-6333 特异性识别并结合 B 细胞恶性肿瘤表面的 CD19 抗原，定位肿瘤细胞。RG-6333 通过与 CD28 结合激活 T 细胞，克服激活障碍，增强抗肿瘤免疫力。RG-6333 能够用于复发/难治性非霍奇金淋巴瘤的研究。推荐同型对照为 human IgG4 kappa，同型对照 (HY-P99003)。

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RG-6333

RG-6333 Chemical Structure

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规格 价格 是否有货
1 mg ￥3500
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RG-6333 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

RG-6333 is a bispecific agonist targeting CD19 and CD28. RG-6333 specifically recognizes and binds to the CD19 antigen on the surface of B-cell malignancies to locate tumor cells. RG-6333 activates T cells by binding to CD28, overcoming activation barriers to enhance anti-tumor immunity. RG-6333 can be used in the study of relapsed/refractory non-Hodgkin's lymphoma. The recommended isotype control is human IgG4 kappa, isotype control (HY-P99003)[1][2].

反应种属

Human
IC50 & Target

CD19 & CD28
体外研究
(In Vitro)

RG-6333 (RO 7443904) 在 CHO 细胞中对 CD28 具有较低的亲和力 (Kd: 36 nM)，结合较弱，但足以提供共刺激信号[1]。
RG-6333 在人外周血单个核细胞 (PBMC) 中单药无活性，仅在 T 细胞受体 (TCR) 参与时激活 T 细胞[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

RG-6333 相关抗体:
体内研究
(In Vivo)

RG-6333 (1,10 mg/kg, i.v. one dose) 在人源化 NSG 小鼠中，仅在 T 细胞受体 (TCR) 信号存在时才能激活T细胞，且不会引起细胞因子风暴[1][2]。
RG-6333 (1 mg/kg, i.v. one dose) 在携带皮下 NALM-6 淋巴瘤的人源化 NSG 小鼠中，联合 Glofitamab (HY-P99024) (0.15 mg/kg) 显著抑制肿瘤生长，并且肿瘤浸润 CD8+ T细胞增加[1]。
RG-6333 (1 mg/kg, i.v. three times) 在侵袭性体内淋巴瘤 (DLBCL WSU-DLCL2-Fluc) 人源化小鼠模型中，联合Glofitamab (0.15 mg/kg) 实现肿瘤完全消退，初期因 T 细胞激活导致短暂体重下降，但随后恢复[1][2]。
RG-6333 (1 mg/kg, i.v. three times) 在携带皮下 OCI-Ly18 肿瘤的人源化 NSG 小鼠模型中，联合 Glofitamab (0.15 mg/kg) 增加肿瘤中的促炎 T 细胞特征并促进跨内皮迁移，此外与 CD19–4-1BBL 的三重组合可加深和延长体内抗肿瘤反应[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Humanized NSG mice bearing orthotopic WSU-DLCL2-Fluc tumors[1]
Dosage: 1 mg/kg
Administration: i.v. three times combined injection
Result: Combined with Glofitamab (0.15 mg/kg) achieved complete tumor regression, with initial weight loss in mice, which is related to the mode of action of TCB and its induced cytokine release.
Combined with Glofitamab (0.15 mg/kg) led to subsequent recovery of mice without additional weight loss suggestive of tumor progression, indicated potent antitumor activity.
Animal Model: OCI-Ly18 tumor-bearing humanized NSG mice[1]
Dosage: 1 mg/kg
Administration: i.v. three times combined injection
Result: Combined with Glofitamab (1 mg/kg) increased intratumoral CD8+ and CD4+ T-cell counts.
Combined with Glofitamab (1 mg/kg) led to a marked increase in IFNγ pathway genes, followed by significantly increased cytotoxic T-cell and decreased B-cell signatures.
Combined with Glofitamab (1 mg/kg) and CD19-4-1BBL (1 mg/kg) prolonged the anti-tumor response in vivo and achieving long-term tumor control.
Clinical Trial
基因 ID

12479  [NCBI] & 12487  [NCBI]

Accession
应用

ELISA, FACS, Functional assay
偶联物

Unconjugated
复溶方法

The product can be reconstituted/diluted with sterile PBS or saline.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

RG-6333 相关分类

  • 摩尔计算器

  • 稀释计算器

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

RG-6333RO7443904RG6333RG 6333RO 7443904RO-7443904CD19CD28immunotherapyhumanized NSG micelymphomaglofitamabInhibitorinhibitorinhibit

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