1. Anti-infection
  2. SARS-CoV
  3. SARS-CoV-2-IN-26

SARS-CoV-2-IN-23 是一种双臂二磷酸酯和中等长度的分子镊子。SARS-CoV-2-IN-23 具有抗病毒活性,抑制 SARS-CoV-2 活力和病毒尖刺伪粒子转导的 IC50 分别为 8.2 μM 和 2.6 μM。SARS-CoV-2-IN-23 引起脂质体膜破坏,EC50 为 4.4 μM。

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SARS-CoV-2-IN-26 Chemical Structure

SARS-CoV-2-IN-26 Chemical Structure

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Customer Review

Other Forms of SARS-CoV-2-IN-26:

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

SARS-CoV-2-IN-23 is a two-armed diphosphate ester and medium length molecular tweezers. SARS-CoV-2-IN-23 exhibits antiviral activity with IC50s of 8.2 μM and 2.6 μM against SARS-CoV-2 activity and the spike pseudoparticle transduction, respectively. SARS-CoV-2-IN-23 induces liposomal membrane disruption with an EC50 value of 4.4 μM[1].

IC50 & Target

IC50: 4.4 μM (viral liposome, SARS-CoV-2)[1]

体外研究
(In Vitro)

SARS-CoV-2-IN-23 (CP002) inhibits SARS-CoV-2 (IC50=2.6 μM) with a low cytotoxicity (Caco2 cells, CC50=97 μM)[1].
SARS-CoV-2-IN-23 (0-15 μM; 2 h) inactivate SARS-CoV-2, shows inhibition against infection with an IC50 value of 8.2 μM[1].
SARS-CoV-2-IN-23 suppresses varies enveloped viruses activity with IC50s of 38.4 μM (influenza A virus, IAV), 2.8 μM (measles virus, MeV), 1.1 μM (herpes simplex viruses, HSV-1), and human immunodeficiency virus type 1 (HIV-1), respectively[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay[1]

Cell Line: Caco2 cells exposed with SARS-CoV-2 (2 h, 37 ℃)
Concentration: 0, 0.23, 0.93, 3.75, 15 μM
Incubation Time: 2 hours; determined infection rates on day 2
Result: Inhibited SARS-CoV-2 infection activity to Caco2 cells.
分子量

866.91

Formula

C52H52O8P2

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

纯度 & 产品资料
参考文献

SARS-CoV-2-IN-26 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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产品名称:
SARS-CoV-2-IN-26
目录号:
HY-151269
需求量: