2. Anti-infection
  3. SARS-CoV Filovirus Hepatitis E Virus (HEV)
  4. SCR005

SCR005 是一种具有广谱抗病毒活性的合成碳水化合物受体 (SCR)。SCR005 抑制多种病毒家族的包膜病毒进入 (冠状病毒科：SARS-CoV-1、SARS-CoV-2、MERS-CoV；丝状病毒科：EBOV、MARV；副黏病毒科：NiV、HeV) 以及糖基化的非包膜轮状病毒。SCR005 结合病毒包膜 N-糖基，阻断病毒与宿主细胞的结合或同时阻断结合和膜融合。SCR005 在感染 SARS-CoV-2 的 hACE2 小鼠中发挥预防作用。SCR005 可用于包膜病毒大流行的研究和预防。

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SCR005

SCR005 Chemical Structure

CAS No. : 2409183-70-4

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SCR005 相关抗体

Top Publications Citing Use of Products

查看 Filovirus 亚型特异性产品:

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EBOV MARV ZEBOV

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

SCR005 is a synthetic carbohydrate receptor (SCR) with broad-spectrum antiviral activity. SCR005 inhibits the entry of enveloped viruses across multiple families (Coronaviridae: SARS-CoV-1, SARS-CoV-2, MERS-CoV; Filoviridae: EBOV, MARV; Paramyxoviridae: NiV, HeV) and the glycosylated nonenveloped rotavirus. SCR005 binds viral envelope N-glycans, blocking viral binding to host cells or both binding and membrane fusion. SCR005 exerts prophylactic effects in hACE2 mice infected with SARS-CoV-2. SCR005 can be used for the study and prevention of enveloped virus pandemics[1].

体外研究
(In Vitro)

SCR005 (10 μM, 30 min) 抑制 SARS-CoV-1、SARS-CoV-2、MERS-CoV、NiV、HeV 和 EBOV 的假型病毒颗粒 (PVPs) 对 VERO-TMPRSS2 细胞的感染[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

SCR005 相关抗体:
体内研究
(In Vivo)

SCR005 (3 mg/kg，鼻内给药，单剂量) 提高感染 SARS-CoV-2 的 hACE2 小鼠的存活率[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: hACE2 knock-in mice (4-5-month-old) were intranasally challenged with 2 × 103 PFU of SARS-CoV-1/2[1]
Dosage: 3 mg/kg
Administration: i.n., single dose
Result: Improved survival rate to 30%.
Decreased lung and brain viral RNA copies by multiple orders of magnitude.
Reduced perivascular infiltrates and necrotic neurons in lung and brain tissues.
Decreased pro-inflammatory cytokine levels in bronchoalveolar lavage fluid (BALF), with IL-18 and IFN-γ reduced.
分子量

578.71

Formula

C36H34N8
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

SCR005 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SCR0052409183-70-4SCR 005SCR-005SARS-CoVFilovirusHepatitis E Virus (HEV)SARS coronavirusHepatitis E VirushACE2 miceSARS-CoV-2SARS-CoV-1MERS-CoVEBOVMARVNiVHeVInhibitorinhibitorinhibit

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产品名称：
SCR005
目录号：
HY-178135
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