1. 一站式药筛
  2. 化合物库
  3. 生物活性化合物库系列
  4. 根据产品特点分类
  5. 可透过中枢神经系统化合物库
可透过中枢神经系统化合物库 - CNS-Penetrant Compound Library

Cat. No.: HY-L028

血脑屏障是一种复杂的大脑微血管网络。它保护大脑免受外部血流环境的影响,并为大脑提供正常功能所需的营养。然而,血脑屏障也是中枢神经系统疾病或脑肿瘤治疗药物运送的主要障碍,因为由于物理屏障 (紧密连接) 的存在,血脑屏障在全身毛细血管中通透性最低。因此,开发能够透过血脑屏障的药物用于治疗脑部疾病,如阿尔茨海默病 (AD)、帕金森病 (PD) 和癫痫等是至关重要的。

MCE 收录了 858 个具有明确报道可以透过血脑屏障的小分子化合物,是开发脑部疾病药物如脑瘤、精神障碍和神经退行性疾病等有效的工具。

我们将在明确您的产品用途后,向符合资质的客户通过定制合成服务的方式提供 MCE 可透过中枢神经系统化合物库,我们为该库中的所有产品提供溶液包装或粉末包装。溶液包装中,843 个产品以 10 mM 浓度提供,15 个产品以 2 mM 浓度提供。

溶液包装中,我们对于溶液状态稳定且溶解度不低于 10 mM 的产品,提供 10 mM 溶液;对于溶液状态稳定且溶解度介于 2~10 mM 的产品,我们提供 2 mM 溶液。

  • 96-well Plate with Peelable Foil Seal
  • 384-well Microplate with Peelable Foil Seal
  • 96-well Storage Tubes with Rack
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Compound Screening Libraries

Top Publications Citing Use of MCE Products

MCE 顾客使用化合物库产品发表的文献

  • 生物活性
  • 产品详情
  • 产品资料
  • 化合物库组成

活性描述 & 特点

Biological Activity

•   A unique collection of 858 bioactive CNS-penetrant compounds for high throughput screening (HTS) and high content screening (HCS).

•   Targets such as Kinases, GPCR and Ion Channels, and more.

•   A useful tool for the discovery of drugs used for brain diseases, such as brain tumors, mental disorders, and neurodegenerative diseases.

•   Bioactivity and safety confirmed by preclinical research and clinical trials. Some inhibitors have been approved by FDA.

•   Structurally diverse, medicinally active, CNS-penetrant and cell permeable.

•   More detailed compound information with structure, IC50, and brief introduction.

•   NMR and HPLC validated to ensure high purity and quality.

•   All compounds are in stock and continuously updated.

产品详情

Product Details

Formulation:

A collection of 858 CNS-penetrant compounds supplied as pre-dissolved Solutions or Solid
Solution: 843 compounds supplied in 10 mM solution, 15 compounds supplied in 2 mM solution.

Layout:

96-well storage tube or 96-well plate: 1st and 12th column are left empty.
384-well plate: the first two columns and the last two columns are left empty.
Compounds with different concentrations or dissolved in different solvents will be put on separate plates. This way of layout may increase the number of plates because there could be three solvents and three concentrations.
If you have other requirements, please let us know.

Container:

96- or 384-well Plate with Peelable Foil Seal; 96-well Format Sample Storage Tube With Screw Cap and Optional 2D Barcode

Storage:

-80°C

Shipping:

Blue ice or dry ice

化合物库组成

Composition

mAChR (43)

COX (33)

HIV (29)

mGluR (21)

nAChR (20)

EGFR (18)

iGluR (16)

CDK (14)

HDAC (9)

mTOR (9)

HSP (7)

PI3K (7)

MMP (6)

FGFR (5)

FLT3 (5)

HSV (5)

PARP (5)

PPAR (5)

Raf (5)

Akt (4)

AMPK (4)

Btk (4)

ERK (4)

MAGL (4)

MEK (4)

STAT (4)

相关服务推荐
定制您专属的化合物库
  •  特定化合物
  •  化合物数量
  •  产品排布图
  •  浓度
  •  形式(固体或溶液)
  •  YES
联系专家定制
  • 96-well Plate with Peelable Foil Seal
  • 384-well Microplate with Peelable Foil Seal
  • 96-well Storage Tubes with Rack

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    产品名称:
    CNS-Penetrant Compound Library
    目录号:
    HY-L028
    需求量: