1. Screening Libraries
  2. Neuronal Signaling Compound Library

神经信号化合物库 - Neuronal Signaling Compound Library

Cat. No.: HY-L013
Library Contents: XLSX PDF SDF

神经信号参与了中枢神经系统的调控机制,如其结构、功能、遗传学和生理学,以及如何应用它来了解神经系统的疾病等。中枢神经系统中的每个信息处理系统都是由神经元和神经胶质组成,神经元进化出独特的胞内信号转导 (细胞内通信) 和胞间信号转导 (细胞间通信) 功能。G 蛋白偶联受体 (GPCRs) 包括 5-HT 受体、组胺受体、阿片受体等,是最大的一类感觉蛋白,是神经信号转导的重要治疗靶点。除此之外,Notch信号,如 β- 和 γ-secretase,在中枢神经系统发展中也扮演多个角色,包括调节神经干细胞 (NSC) 增殖、生存、自我更新和分化等。受体突变和环境挑战引起的 GPCR 功能障碍是许多神经系统疾病的重要原因。神经元、神经胶质细胞和神经干细胞中的 Notch 信号通路也参与了脑卒中、阿尔茨海默病和中枢神经系统肿瘤等疾病的病理变化。因此,靶向神经信号,如 Notch 信号和 GPCRs,可以作为几种不同的中枢神经系统疾病的治疗干预手段。

MCE 收录了 2052 种神经信号相关的小分子化合物,是研究神经调控及神经疾病的有用工具。

我们将在明确您的产品用途后,向符合资质的客户通过定制合成服务的方式提供 MCE 神经信号化合物库,我们为该库中的所有产品提供溶液包装或粉末包装。溶液包装中,2008 个产品以 10 mM 浓度提供,44 个产品以 2 mM 浓度提供。

溶液包装中,我们对于溶液状态稳定且溶解度不低于 10 mM 的产品,提供 10 mM 溶液;对于溶液状态稳定且溶解度介于 2~10 mM 的产品,我们提供 2 mM 溶液。

  • 96-well Plate with Peelable Foil Seal
  • 384-well Microplate with Peelable Foil Seal
  • 96-well Storage Tubes with Rack
规格 (Pre-dissolved Solution or Solid) 价格 是否有货
30 μL/well Solution

10 mM and 2 mM
Pre-dissolved Solution

立刻询价 In-stock
50 μL/well Solution

10 mM and 2 mM
Pre-dissolved Solution

立刻询价 In-stock
100 μL/well Solution

10 mM and 2 mM
Pre-dissolved Solution

立刻询价 In-stock
2 × 100 μL/well Solution

10 mM and 2 mM
Pre-dissolved Solution

立刻询价 In-stock

Please contact us at

sales@MedChemExpress.cn

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  • 产品详情

  • 化合物库组成

  • 产品资料

活性描述 & 特点

•   A unique collection of 2052 Neuronal Signaling-related compounds for high throughput screening (HTS) and high content screening (HCS).

•   Targets such as 5-HT Receptor, AChE, Adrenergic Receptor, AMPAR, Beta-secretase, Dopamine Receptor, FAAH, Melatonin Receptor, AChR, Opioid Receptor, γ-secretase, etc.

•   A useful tool for the research of neuronal regulation and neuronal diseases.

•   Bioactivity and safety confirmed by preclinical research and clinical trials. Some inhibitors have been approved by FDA.

•   Structurally diverse, medicinally active, and cell permeable.

•   More detailed compound information with structure, IC50, and brief introduction.

•   NMR and HPLC validated to ensure high purity and quality.

•   All compounds are in stock and continuously updated.

产品详情
Formulation:
A collection of 2052 Neuronal Signaling related compounds supplied as pre-dissolved Solutions or Solid
Solution: 2008 compounds supplied in 10 mM solution, 44 compounds supplied in 2 mM solution.
Layout:
96-well storage tube or 96-well plate: 1st and 12th column are left empty.
384-well plate: the first two columns and the last two columns are left empty.
Compounds with different concentrations or dissolved in different solvents will be put on separate plates. This way of layout may increase the number of plates because there could be three solvents and three concentrations.
If you have other requirements, please let us know.
Container:
96- or 384-well Plate with Peelable Foil Seal; 96-well Format Sample Storage Tube With Screw Cap and Optional 2D Barcode
Storage:
-80°C
Shipping:
Blue ice
化合物库组成

Neuronal Signaling Compound Library

Source: MedChem Express

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    产品名称:
    Neuronal Signaling Compound Library
    目录号:
    HY-L013
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    • 96-well Plate with Peelable Foil Seal
    • 384-well Microplate with Peelable Foil Seal
    • 96-well Storage Tubes with Rack
    • 96-well Storage Tubes with Rack