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  2. 化合物库
  3. 生物活性化合物库系列
  4. 疾病相关化合物库
  5. 抗阿尔茨海默病化合物库
抗阿尔茨海默病化合物库 - Anti-Alzheimer's Disease Compound Library

Cat. No.: HY-L069

阿尔茨海默病 (Alzheimer’s Disease, AD) 是一种脑退行性疾病,会引起精神和身体衰退,并逐渐导致死亡。尽管阿尔茨海默病给人类健康带来严重威胁,但只有少数药物得到批准用于该病的治疗,而且这些药物的作用是控制症状,而不是改变疾病的进程。新的治疗方法的开发离不开对阿尔兹海默病机制的研究。最近的研究使人们对阿尔茨海默病 (AD) 的神经生物学有了更深入的了解,并确定了药物开发的独特靶点。通过对大量病例及临床结果的分析研究,科研人员提出了多种不同的理论假说试图阐明阿尔茨海默病的发病过程,其中广为接受并开展药物设计与研究的有如下几种:β-淀粉样蛋白假说 (Amyloid cascade hypothesis) 、Tau蛋白假说 (Tau hypothesis) 和胆碱能假说 (Cholinergic hypothesis) 等。

MCE 收录了 1345 种具有抗阿尔兹海默病活性的化合物及靶向阿尔兹海默病主要靶点的化合物。MCE 抗阿尔兹海默病化合物是研究阿尔兹海默病发病机制及开发抗阿尔兹海默病药物的有用工具。

我们将在明确您的产品用途后,向符合资质的客户通过定制合成服务的方式提供 MCE 抗阿尔茨海默病化合物库,我们为该库中的所有产品提供溶液包装或粉末包装。溶液包装中,1325 个产品以 10 mM 浓度提供,20 个产品以 2 mM 浓度提供。

溶液包装中,我们对于溶液状态稳定且溶解度不低于 10 mM 的产品,提供 10 mM 溶液;对于溶液状态稳定且溶解度介于 2~10 mM 的产品,我们提供 2 mM 溶液。

  • 96-well Plate with Peelable Foil Seal
  • 384-well Microplate with Peelable Foil Seal
  • 96-well Storage Tubes with Rack
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Compound Screening Libraries

Top Publications Citing Use of MCE Products

MCE 顾客使用化合物库产品发表的文献

  • 生物活性
  • 产品详情
  • 产品资料
  • 化合物库组成

活性描述 & 特点

Biological Activity

•   A unique collection of 1345 compounds for high throughput screening (HTS) and high content screening (HCS).

•   Targets include Amyloid-β, 5-HT Receptor, nAChR,etc.

•   A useful tool for exploring the mechanism of Alzheimer's disease and looking for new treatments.

•   Bioactivity and safety confirmed by preclinical research and clinical trials. Some have been approved by FDA.

•   Structurally diverse, medicinally active, and cell permeable.

•   Detailed compound information with structure, IC50, and brief introduction.

•   Validated NMR and HPLC to ensure high purity and quality.

•   All compounds are in stock and continuously updated.

产品详情

Product Details

Formulation:

A collection of 1345 anti-Alzheimer’s Disease compounds supplied as pre-dissolved Solutions or Solid
Solution: 1325 compounds supplied in 10 mM solution, 20 compounds supplied in 2 mM solution.

Layout:

96-well storage tube or 96-well plate: 1st and 12th column are left empty.
384-well plate: the first two columns and the last two columns are left empty.
Compounds with different concentrations or dissolved in different solvents will be put on separate plates. This way of layout may increase the number of plates because there could be three solvents and three concentrations.
If you have other requirements, please let us know.

Container:

96- or 384-well Plate with Peelable Foil Seal; 96-well Format Sample Storage Tube With Screw Cap and Optional 2D Barcode

Storage:

-80°C

Shipping:

Blue ice

化合物库组成

Composition

iGluR (78)

GSK-3 (66)

nAChR (59)

CDK (18)

mAChR (18)

Src (12)

ERK (7)

Wnt (7)

FLT3 (6)

DYRK (5)

HDAC (5)

COX (4)

HIV (4)

JAK (4)

mTOR (4)

PKA (4)

PKC (4)

PPAR (4)

EGFR (3)

FGFR (3)

GlyT (3)

JNK (3)

PI3K (3)

Akt (2)

AMPK (2)

CFTR (2)

COMT (2)

CXCR (2)

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  • 96-well Plate with Peelable Foil Seal
  • 384-well Microplate with Peelable Foil Seal
  • 96-well Storage Tubes with Rack

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    产品名称:
    Anti-Alzheimer's Disease Compound Library
    目录号:
    HY-L069
    需求量: