2. 一站式药筛
  3. 化合物库
  4. 生物活性化合物库系列
  5. 疾病相关化合物库
  6. 抗胰腺癌化合物库
抗胰腺癌化合物库 - Anti-Pancreatic Cancer Compound Library

Cat. No.: HY-L077

胰腺癌是一种预后较差，死亡率很高的恶性肿瘤。化疗仍然是晚期胰腺癌患者最常用的治疗方法。尽管化疗取得了很大进展，但并没有明显提高胰腺癌患者的生存率。最近，靶向治疗为胰腺癌患者带来新的希望。胰腺癌中常见的突变基因包括 K-Ras（74-100%）、p16INK4a（高达98%）、p53（43-76%）、DPC4（约50%）、HER-2/neu（约65%）和FHIT（70%）。其他相关基因包括 Notch1、Akt-2、BRCA2 和 COX- 2 等。这些蛋白是胰腺癌靶向治疗的重要靶点。

MCE 提供 2663 个具有明确或潜在抗胰腺癌活性的化合物，这些化合物靶向 K-Ras、 p53、 HER2、 Notch、 AKT 等胰腺癌治疗中的关键靶点及信号通路。MCE 抗胰腺癌化合物库是筛选抗胰腺癌药物及其他胰腺癌相关研究的重要工具。

我们将在明确您的产品用途后，向符合资质的客户通过定制合成服务的方式提供 MCE 抗胰腺癌化合物库，我们为该库中的所有产品提供溶液包装或粉末包装。溶液包装中，2601 个产品以 10 mM 浓度提供，56 个产品以 2 mM 浓度提供，6 个产品以 3 mg/mL 浓度提供。

溶液包装中，我们对于溶液状态稳定且溶解度不低于 10 mM 的产品，提供 10 mM 溶液；对于溶液状态稳定且溶解度介于 2~10 mM 的产品，我们提供 2 mM 溶液；对于溶液状态稳定、分子量不确定且溶解度不低于 3 mg/mL产品，我们提供 3 mg/mL 溶液。

  • 96-well Plate with Peelable Foil Seal
  • 384-well Microplate with Peelable Foil Seal
  • 96-well Storage Tubes with Rack
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Compound Screening Libraries

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MCE 顾客使用化合物库产品发表的文献

  • 生物活性
  • 产品详情
  • 产品资料
  • 化合物库组成

活性描述 & 特点

Biological Activity

•   A unique collection of 2663 compounds with identified and potential anti-pancreatic cancer activity for high throughput screening (HTS) and high content screening (HCS).

•   Targets include K-Ras, p53, HER2, Notch, AKT, PI3K, AKT, COX etc.

•   A useful tool for the discovery of anti-pancreatic cancer drugs.

•   Bioactivity and safety confirmed by preclinical research and clinical trials. Some have been approved by FDA.

•   Structurally diverse, medicinally active, and cell permeable.

•   Detailed compound information with structure, IC50, and brief introduction.

•   Validated NMR and HPLC to ensure high purity and quality.

•   All compounds are in stock and continuously updated.

产品详情

Product Details

Formulation:

A collection of 2663 anti-pancreatic cancer compounds supplied as pre-dissolved Solutions or Solid
Solution: 2601 compounds supplied in 10 mM solution, 56 compounds supplied in 2 mM solution, 6 compounds supplied in 3 mg/mL solution.

Layout:

96-well storage tube or 96-well plate: 1st and 12th column are left empty.
384-well plate: the first two columns and the last two columns are left empty.
Compounds with different concentrations or dissolved in different solvents will be put on separate plates. This way of layout may increase the number of plates because there could be three solvents and three concentrations.
If you have other requirements, please let us know.

Container:

96- or 384-well Plate with Peelable Foil Seal; 96-well Format Sample Storage Tube With Screw Cap and Optional 2D Barcode

Storage:

-80°C

Shipping:

Blue ice

化合物库组成

Composition

NF-κB (257)

PI3K (191)

EGFR (186)

VEGFR (152)

COX (145)

Akt (134)

HDAC (129)

JAK (122)

PARP (108)

STAT (107)

CDK (100)

MMP (99)

mTOR (99)

Ras (96)

Src (74)

AMPK (72)

GSK-3 (72)

ERK (64)

PDGFR (59)

Raf (55)

FGFR (45)

c-Kit (37)

FLT3 (36)

FAK (34)

HIV (34)

MEK (31)

Smo (30)

Notch (26)

Pim (23)

JNK (17)

HSV (15)

PKC (15)

PI4K (14)

PDK-1 (13)

PPAR (13)

RET (13)

Wnt (11)

c-Fms (10)

HSP (10)

Btk (9)

相关服务推荐
定制您专属的化合物库
  •  特定化合物
  •  化合物数量
  •  产品排布图
  •  浓度
  •  形式（固体或溶液）
  •  YES
联系专家定制
  • 96-well Plate with Peelable Foil Seal
  • 384-well Microplate with Peelable Foil Seal
  • 96-well Storage Tubes with Rack
  • 96-well Plate with Peelable Foil Seal
  • 384-well Microplate with Peelable Foil Seal
  • 96-well Storage Tubes with Rack

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    Anti-Pancreatic Cancer Compound Library
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