2. 一站式药筛
  3. 化合物库
  4. 靶向半胱氨酸蛋白酶共价化合物库
靶向半胱氨酸蛋白酶共价化合物库 - Cysteine Protease Focused Covalent Library

Cat. No.: HY-L926

半胱氨酸蛋白酶（CPs）作为调控生理代谢并介导病理过程（如异常骨吸收、肿瘤侵袭及病原体感染）的关键酶家族，通过开发特异性抑制剂已成为疾病干预的核心治疗靶点。目前报道的CP共价抑制剂涵盖多种结构类型，包括环氧化物、氮丙啶、活化双键（乙烯磺酰、α,β-不饱和酮）等。这为开发新型CP共价抑制剂提供了明确的结构参考。

本化合物库包含多种弹头可以和半胱氨酸蛋白酶发生共价相互作用，是高效发现新型半胱氨酸蛋白酶共价抑制剂的有用工具。

  • 96-well Plate with Peelable Foil Seal
  • 384-well Microplate with Peelable Foil Seal
  • 96-well Storage Tubes with Rack
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  • 生物活性
  • 产品详情

活性描述 & 特点

Biological Activity

•    A unique collection of 2,000 compounds can be used for efficient discovery of novel cysteine protease covalent inhibitors.

•    All compounds feature warheads capable of forming covalent interactions with cysteine proteases.

•    All compounds are available off the shelf.

•    All compounds are validated by LC-MS or NMR to ensure high purity and quality.

产品详情

Product Details

Formulation:

The 2,000 compounds feature covalent warheads targeting cysteine proteases, establishing the library as a valuable tool for discovering novel cysteine covalent protease inhibitors.

Layout:

96-well storage tube or 96-well plate: 1st and 12th column are left empty.
384-well plate: the first two columns and the last two columns are left empty.
Compounds with different concentrations or dissolved in different solvents will be put on separate plates. This way of layout may increase the number of plates because there could be three solvents and three concentrations.
If you have other requirements, please let us know.

Container:

96- or 384-well Plate with Peelable Foil Seal; 96-well Format Sample Storage Tube With Screw Cap and Optional 2D Barcode.

Storage:

-80°C

Shipping:

Blue ice or dry ice

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  • 96-well Plate with Peelable Foil Seal
  • 384-well Microplate with Peelable Foil Seal
  • 96-well Storage Tubes with Rack
  • 96-well Plate with Peelable Foil Seal
  • 384-well Microplate with Peelable Foil Seal
  • 96-well Storage Tubes with Rack

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    产品名称：
    Cysteine Protease Focused Covalent Library
    目录号：
    HY-L926
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