1. 一站式药筛
  2. 化合物库
  3. 生物活性化合物库系列
  4. 根据产品结构分类
  5. 大环类化合物库
大环类化合物库 - Macrocyclic Compound Library

Cat. No.: HY-L041

大环化合物是指含有 12 元或更大环的分子,在小分子药物开发中越来越受到重视。主要原因包括:大环类化合物提供了新的化学空间,挑战新的蛋白质靶标,另外,一些大环类药物也显示出较好的药代动力学性能。大环类化合物对于比较具有挑战性的靶点的药物开发具有一定优势,特别是在调节大分子之间相互作用如蛋白蛋白相互作用方面。此外,大环化合物的大小和复杂性使其能够保证更大的空间分布的结合相互作用,从而增加结合亲和力和选择性。

MCE 提供 364 个大环类化合物,可以用于高通量筛选和高内涵筛选。MCE 大环类化合物库是新药开发的有利工具,尤其对于“难成药”靶点及蛋白互作的新药研发。

  • 96-well Plate with Peelable Foil Seal
- +

Compound Screening Libraries

Top Publications Citing Use of MCE Products

MCE 顾客使用化合物库产品发表的文献

  • 生物活性
  • 产品详情
  • 产品资料
  • 化合物库组成

活性描述 & 特点

Biological Activity

•   A unique collection of 364 macrocyclic compounds that for drug discovery.

•   A useful tool for the discovery of "undruggable" targets such as protein-protein interactions (PPIs) inhibitors.

•   Cyclopeptides, crown ethers, calixarene and so on are included.

•   More detailed compound information with structure, IC50, and other chemical & biological data.

•   NMR and HPLC validated ensure high purity.

•   All compounds are in stock and continuously updated.

产品详情

Product Details

Formulation:

A collection of 364 macrocyclic compounds supplied as Solid

Layout:

96-well storage tube or 96-well plate: 1st and 12th column are left empty.
384-well plate: the first two columns and the last two columns are left empty.
Compounds with different concentrations or dissolved in different solvents will be put on separate plates. This way of layout may increase the number of plates because there could be three solvents and three concentrations.
If you have other requirements, please let us know.

Container:

96-well Storage Tubes with Rack

Storage:

-80°C

Shipping:

Blue ice

化合物库组成

Composition

HCV (9)

HIV (9)

mTOR (8)

CXCR (6)

FKBP (6)

Ras (5)

HSP (4)

FLT3 (3)

HSV (3)

PKC (3)

CDK (2)

ERK (2)

JAK (2)

MMP (2)

PI3K (2)

YAP (2)

Akt (1)

BCRP (1)

EBV (1)

EGFR (1)

FAK (1)

相关服务推荐
定制您专属的化合物库
  •  特定化合物
  •  化合物数量
  •  产品排布图
  •  浓度
  •  形式(固体或溶液)
  •  YES
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  • 96-well Plate with Peelable Foil Seal

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    产品名称:
    Macrocyclic Compound Library
    目录号:
    HY-L041
    需求量: