1. Screening Libraries
  2. Covalent Screening Library Plus

共价化合物库 Plus - Covalent Screening Library Plus

Cat. No.: HY-L036P
Library Contents: XLSX PDF SDF

小分子共价抑制剂,又称不可逆抑制剂,是一类通过共价键不可逆地与靶点结合来发挥其生物学功能的抑制剂。与非共价抑制剂相比,共价抑制剂在生物活性方面具有明显优势,共价弹头靶向特定靶蛋白的稀有残基,可以用于开发高选择性抑制剂。近年来,共价抑制剂在解决耐药性问题方面表现出显著优势,受到广泛认可。但是此类抑制剂一旦出现脱靶,也将带来更强的毒副作用。因此,通过合理的筛选设计和结构修饰发现共价抑制剂药物也逐渐成为一个药物研发的焦点。

MCE 共价化合物库 Plus 收录了 3493 种小分子抑制剂,包括已知共价抑制剂及具有共价反应基团的活性小分子化合物,如包含丙烯酰胺、活化末端乙炔、磺酰氟化物/酯、氯乙酰胺、烷基卤化物、环氧化物、氮杂环胺、二硫化物等,是筛选共价化合物,研究共价作用机制的有利工具。

MCE 共价化合物库 Plus 是对 MCE 共价化合物(HY-L036)的补充,增加了一些具有共价弹头的片段分子,具有更强的筛选能力。

我们将在明确您的产品用途后,向符合资质的客户通过定制合成服务的方式提供 MCE 共价化合物库 Plus,我们为该库中的所有产品提供溶液包装或粉末包装。溶液包装中,3463 个产品以 10 mM 浓度提供,4 个产品以 2 mM 浓度提供。

溶液包装中,我们对于溶液状态稳定且溶解度不低于 10 mM 的产品,提供 10 mM 溶液;对于溶液状态稳定且溶解度介于 2~10 mM 的产品,我们提供 2 mM 溶液。

  • 96-well Plate with Peelable Foil Seal
  • 384-well Microplate with Peelable Foil Seal
  • 96-well Storage Tubes with Rack
Size (Pre-dissolved Solution or Solid) Price Stock
50 μL/well Solution

10 mM and 2 mM
Pre-dissolved Solution

Get quote In-stock
100 μL/well Solution

10 mM and 2 mM
Pre-dissolved Solution

Get quote In-stock
2 × 100 μL/well Solution

10 mM and 2 mM
Pre-dissolved Solution

Get quote In-stock

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sales@MedChemExpress.cn

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Description
& Advantages

•   A unique collection of 3493 compounds that show irreversible covalent binding with target proteins for high throughput screening (HTS) and high content screening (HCS).

•   Chemical probes that show enhanced selectivity, potency and utility for biological studies.

•   A useful tool for drug discovery with irreversible inhibition.

•   Structurally diverse, medicinally active, and cell permeable.

•   Detailed compound information with structure, IC50, and brief introduction.

•   Validated NMR and HPLC to ensure high purity and quality.

•   All compounds are in stock and continuously updated.

Product Details
Formulation:
A collection of 3493 molecules supplied as pre-dissolved Solutions or Solid
Solution: 3463 compounds supplied in 10 mM solution, 4 compounds supplied in 2 mM solution.
Container:
96- or 384-well Plate with Peelable Foil Seal
Storage:
-80°C
Shipping:
Blue ice
Documentation

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    产品名称:
    Covalent Screening Library Plus
    目录号:
    HY-L036P
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    • 96-well Plate with Peelable Foil Seal
    • 384-well Microplate with Peelable Foil Seal
    • 96-well Storage Tubes with Rack