1. 一站式药筛
  2. 化合物库
  3. 生物活性化合物库系列
  4. 信号通路化合物库系列
  5. 膜蛋白靶向化合物库
膜蛋白靶向化合物库 - Membrane Protein-targeted Compound Library

Cat. No.: HY-L149

膜蛋白是附着在细胞膜或细胞器上的蛋白质分子。 膜蛋白可根据其与膜的结合方式分为两类:整合膜蛋白(也称为内在膜蛋白或脂锚定膜蛋白)和外周膜蛋白(也称为外在膜蛋白)。 在人体中,大约30%的基因组编码膜蛋白。 膜蛋白在生物的生存中发挥多种重要功能,如信号转导、分子或离子转运、酶催化和细胞间通讯等。 膜蛋白在药物开发中也发挥着重要作用。 据报道,目前超过60%的药物靶点均是膜蛋白。

MCE可以提供6592种膜蛋白靶向化合物,可以用于膜蛋白靶向筛选或药物开发。

我们将在明确您的产品用途后,向符合资质的客户通过定制合成服务的方式提供 MCE 膜蛋白靶向化合物库,我们为该库中的所有产品提供溶液包装或粉末包装。溶液包装中,6475 个产品以 10 mM 浓度提供,111 个产品以 2 mM 浓度提供,6 个产品以 3 mg/mL 浓度提供。

溶液包装中,我们对于溶液状态稳定且溶解度不低于 10 mM 的产品,提供 10 mM 溶液;对于溶液状态稳定且溶解度介于 2~10 mM 的产品,我们提供 2 mM 溶液;对于溶液状态稳定、分子量不确定且溶解度不低于 3 mg/mL产品,我们提供 3 mg/mL 溶液。

  • 96-well Plate with Peelable Foil Seal
  • 384-well Microplate with Peelable Foil Seal
  • 96-well Storage Tubes with Rack
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Compound Screening Libraries

Top Publications Citing Use of MCE Products

MCE 顾客使用化合物库产品发表的文献

  • 生物活性
  • 产品详情
  • 产品资料
  • 化合物库组成

活性描述 & 特点

Biological Activity

•   A unique collection of 6592 small molecules targeting variety of membrane proteins.

•    Targets such as GLUT, GABA Receptor, VEGFR, GPR88, Adrenergic Receptor, 5-HT Receptor, ion channel, etc.

•   All of the small molecules in this library are well characterized with biological and pharmaceutical activity. Some compounds have been approved by the FDA.

•    A powerful tool for discovering membrane protein-based drugs.

•   Structurally diverse, medicinally active, and cell permeable.

•   NMR and HPLC validated to ensure the highest purity.

•   All compounds are in stock and continuously updated.

产品详情

Product Details

Formulation:

A collection of 6592 membrane proteins-related compounds supplied as pre-dissolved Solutions or Solid.
Solution: 6475 compounds supplied in 10 mM solution, 111 compounds supplied in 2 mM solution, 6 compounds supplied in 3 mg/mL solution.

Layout:

96-well storage tube or 96-well plate: 1st and 12th column are left empty.
384-well plate: the first two columns and the last two columns are left empty.
Compounds with different concentrations or dissolved in different solvents will be put on separate plates. This way of layout may increase the number of plates because there could be three solvents and three concentrations.
If you have other requirements, please let us know.

Container:

96- or 384-well Plate with Peelable Foil Seal; 96-well Format Sample Storage Tube With Screw Cap and Optional 2D Barcode.

Storage:

-80°C

Shipping:

Blue ice or dry ice

化合物库组成

Composition

CDK (225)

PI3K (185)

EGFR (182)

iGluR (151)

mAChR (148)

VEGFR (144)

Akt (125)

mGluR (109)

Caspase (103)

MMP (93)

Ras (92)

nAChR (91)

FGFR (83)

PDGFR (83)

FLT3 (82)

HSP (80)

PKC (78)

GSK-3 (70)

Src (70)

Btk (60)

c-Kit (57)

CCR (57)

Raf (55)

ROCK (53)

CXCR (50)

HIV (49)

mTOR (49)

ERK (47)

COX (38)

Wnt (38)

FAK (34)

c-Fms (33)

CFTR (33)

RET (30)

相关服务推荐
定制您专属的化合物库
  •  特定化合物
  •  化合物数量
  •  产品排布图
  •  浓度
  •  形式(固体或溶液)
  •  YES
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  • 96-well Plate with Peelable Foil Seal
  • 384-well Microplate with Peelable Foil Seal
  • 96-well Storage Tubes with Rack

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    产品名称:
    Membrane Protein-targeted Compound Library
    目录号:
    HY-L149
    需求量: