1. 一站式药筛
  2. 化合物库
  3. 生物活性化合物库系列
  4. 信号通路化合物库系列
  5. 膜受体靶向化合物库
膜受体靶向化合物库 - Membrane Receptor-targeted Compound Library

Cat. No.: HY-L150

膜受体,也称为细胞表面受体或跨膜受体,是嵌入质膜的跨膜蛋白,在维持细胞内部过程与各种细胞外信号之间的通信中起着重要作用。 这些膜受体通过与细胞外分子结合在细胞信号传导中发挥作用,与膜受体结合的细胞外分子也称为配体。 这些细胞外分子包括激素、细胞因子、生长因子、神经递质、亲脂性信号分子如前列腺素和细胞识别分子。

存在三种不同的膜受体:离子通道受体、G蛋白偶联受体和酶偶联受体。它们在维持人体正常生理过程中起着重要作用。GPCRs和离子通道也是药物发现中的重要靶点。

MCE可以提供4476种膜受体靶向化合物,可以用于膜受体靶向筛选或药物开发。

我们将在明确您的产品用途后,向符合资质的客户通过定制合成服务的方式提供 MCE 膜受体靶向化合物库,我们为该库中的所有产品提供溶液包装或粉末包装。溶液包装中,4407 个产品以 10 mM 浓度提供,66 个产品以 2 mM 浓度提供,3 个产品以 3 mg/mL 浓度提供。

溶液包装中,我们对于溶液状态稳定且溶解度不低于 10 mM 的产品,提供 10 mM 溶液;对于溶液状态稳定且溶解度介于 2~10 mM 的产品,我们提供 2 mM 溶液;对于溶液状态稳定、分子量不确定且溶解度不低于 3 mg/mL产品,我们提供 3 mg/mL 溶液。

  • 96-well Plate with Peelable Foil Seal
  • 384-well Microplate with Peelable Foil Seal
  • 96-well Storage Tubes with Rack
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Compound Screening Libraries

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MCE 顾客使用化合物库产品发表的文献

  • 生物活性
  • 产品详情
  • 产品资料
  • 化合物库组成

活性描述 & 特点

Biological Activity

•   A unique collection of 4476 small molecules targeting variety of membrane receptors.

•    Targets such as FGFR, TRP Channel, VEGFR, TNF Receptor, Opioid Receptor, 5-HT Receptor, ion channel, etc.

•   All of the small molecules in this library are well characterized with biological and pharmaceutical activity. Some compounds have been approved by the FDA.

•    A powerful tool for discovering membrane receptor-based drugs.

•   Structurally diverse, medicinally active, and cell permeable.

•   NMR and HPLC validated to ensure the highest purity.

•   All compounds are in stock and continuously updated.

产品详情

Product Details

Formulation:

A collection of 4476 membrane receptor-related compounds supplied as pre-dissolved Solutions or Solid.
Solution: 4407 compounds supplied in 10 mM solution, 66 compounds supplied in 2 mM solution, 3 compounds supplied in 3 mg/mL solution.

Layout:

96-well storage tube or 96-well plate: 1st and 12th column are left empty.
384-well plate: the first two columns and the last two columns are left empty.
Compounds with different concentrations or dissolved in different solvents will be put on separate plates. This way of layout may increase the number of plates because there could be three solvents and three concentrations.
If you have other requirements, please let us know.

Container:

96- or 384-well Plate with Peelable Foil Seal; 96-well Format Sample Storage Tube With Screw Cap and Optional 2D Barcode.

Storage:

-80°C

Shipping:

Blue ice or dry ice

化合物库组成

Composition

EGFR (182)

iGluR (151)

mAChR (148)

VEGFR (144)

mGluR (109)

Ras (92)

nAChR (91)

FGFR (83)

PDGFR (83)

CCR (57)

Raf (55)

CXCR (50)

c-Kit (44)

FLT3 (35)

CFTR (33)

HIV (30)

RET (30)

GCGR (26)

Src (23)

Akt (21)

COX (21)

ERK (21)

SGLT (20)

GLUT (18)

PPAR (16)

CaSR (15)

BCRP (14)

相关服务推荐
定制您专属的化合物库
  •  特定化合物
  •  化合物数量
  •  产品排布图
  •  浓度
  •  形式(固体或溶液)
  •  YES
联系专家定制
  • 96-well Plate with Peelable Foil Seal
  • 384-well Microplate with Peelable Foil Seal
  • 96-well Storage Tubes with Rack

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    产品名称:
    Membrane Receptor-targeted Compound Library
    目录号:
    HY-L150
    需求量: