1. GPCR/G Protein
  2. Vasopressin Receptor
  3. Selepressin

Selepressin  (Synonyms: FE 202158)

目录号: HY-105239
产品使用指南

Selepressin (FE 202158) 是一种选择性的加压素 V1A 受体 (vasopressin V1A receptor) 激动剂。Selepressin 是一种有效的血管加压素。Selepressin 可用于脓毒性休克的研究。

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Selepressin Chemical Structure

Selepressin Chemical Structure

CAS No. : 876296-47-8

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Selepressin 的其他形式现货产品:

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查看 Vasopressin Receptor 亚型特异性产品:

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Selepressin (FE 202158) is a selective vasopressin V1A receptor agonist. Selepressin is a potent vasopressor. Selepressin can be used in the research of septic shock[1][2][4].

体外研究
(In Vitro)

Selepressin (100 nM, 48 or 72 h) ameliorates thrombin or VEGF-induced HLMVECs barrier dysfunction[3].
Selepressin (1-1000 nM, 72 h) prevents the LPS-Induced loss of VE-cadherin and cortical actin in HLMVECs[3].
Selepressin (100 nM, 48 h) induces the expression of the barrier-protective p53 in HLMVECs[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis[2]

Cell Line: HLMVECs
Concentration: 1, 10, 100, 1000 nM
Incubation Time: 24 h, 48 h
Result: Induced p53 expression levels, but only after treatment of 48 hours at 100 nM.
体内研究
(In Vivo)

Selepressin (1 μg/kg/min, left jugular vein infusion for 12 min) increases 38.5% of the mean arterial pressure (MAP) in LPS-induced, fluid-resuscitated rabbit endotoxemia model[2].
Selepressin (7 pmol/kg/min, 10 μL/min, i.v. infusion) blocks vascular leak in ovine severe sepsis[4].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: LPS-induced, fluid-resuscitated rabbit endotoxemia model[2].
Dosage: 1 μg/kg/min
Administration: Left jugular vein infusion for 12 min
Result: Decreased mesenteric blood flow (MBF) and increased mesenteric vascular resistance in non-endotoxemic and endotoxemic rabbits.
Clinical Trial
分子量

1048.28

Formula

C46H73N13O11S2

CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

纯度 & 产品资料
参考文献
  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Selepressin
目录号:
HY-105239
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