2. Metabolic Enzyme/Protease
  3. Mitochondrial Metabolism
  4. SH-BC-893

SH-BC-893 是一种抗肿瘤鞘脂类似物，具有口服活性。SH-BC-893 还可以防止神经酰胺引起的线粒体功能障碍并纠正饮食引起的肥胖。SH-BC-893 可用于癌症和肥胖症的研究。

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SH-BC-893

SH-BC-893 Chemical Structure

CAS No. : 1841409-92-4

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1 mg ￥5800
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Customer Review

SH-BC-893 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

SH-BC-893 is an orally active anti-neoplastic sphingolipid analog. SH-BC-893 also protects from ceramide-induced mitochondrial dysfunction and corrects diet-induced obesity. SH-BC-893 can be used for the research of cancer and obesity[1][2].

细胞效力
(Cellular Effect)
Cell Line Type Value Description References
FL5.12 IC50
1.8 μM
Compound: 3; SH-BC-893
Inhibition of protein phosphatase 2A in mouse FL5.12 cells assessed as reduction in cell viability incubated for 48 hrs by propidium iodide staining based flow cytometric analysis
Inhibition of protein phosphatase 2A in mouse FL5.12 cells assessed as reduction in cell viability incubated for 48 hrs by propidium iodide staining based flow cytometric analysis
[PMID: 31383588]
FL5.12 IC50
1.9 μM
Compound: 4
Cytotoxicity against mouse FL5.12A cells after 48 hrs by DAPI staining-based flow cytometric analysis
Cytotoxicity against mouse FL5.12A cells after 48 hrs by DAPI staining-based flow cytometric analysis
[PMID: 27475534]
体外研究
(In Vitro)

SH-BC-893 通过下调细胞表面营养转运蛋白和阻断溶酶体运输事件来饿死癌细胞[1]。
SH-BC-893（5 μM；3 小时）通过破坏细胞内运输来防止神经酰胺诱导的线粒体网络断裂[2]。
SH-BC-893（8.935 nM；3 小时）防止神经酰胺诱导的线粒体功能障碍[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

SH-BC-893 相关抗体:

Western Blot Analysis[1]

Cell Line: p53 flox/flox MEFs
Concentration: 5 μM
Incubation Time: 3 h
Result: Blocked palmitate-induced recruitment of DRP1 to mitochondria without affecting DRP1 protein levels.

Immunofluorescence[1]

Cell Line: p53 flox/flox MEFs
Concentration: 5 μM
Incubation Time: 3 h
Result: Blocked palmitate-induced recruitment of DRP1 to mitochondria.
体内研究
(In Vivo)

SH-BC-893（口服；120 mg/kg；单次）强烈而敏锐地阻断神经酰胺诱导的线粒体功能障碍，纠正饮食诱导的肥胖及其代谢后遗症[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: C57BL/6J mice (Male)[1]
Dosage: 120 mg/kg
Administration: Oral; single
Result: Blocked palmitate- and ceramide-induced mitochondrial fission, preserved mitochondrial function, and prevented ER stress.
Normalized mitochondrial morphology in the livers and brains of HFD-fed mice, improved mitochondrial function in white adipose tissue, and corrected aberrant plasma leptin and adiponectin levels.
Restored normal body weight, glucose disposal, and hepatic lipid levels in mice consuming a HFD.
分子量

325.92

Formula

C19H32ClNO
CAS 号
性状

液体

颜色

Colorless to light yellow

运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

纯度 & 产品资料

纯度: 98.03%

COA (188 KB) HNMR (256 KB) RP-HPLC (263 KB)

产品使用指南 (1538 KB)
参考文献

SH-BC-893 相关分类

  • 摩尔计算器

  • 稀释计算器

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SH-BC-8931841409-92-4Mitochondrial Metabolismoralsphingolipid analogceramide-induced mitochondrial dysfunctiondiet-induced obesityInhibitorinhibitorinhibit

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产品名称：
SH-BC-893
目录号：
HY-124758
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