1. Anti-infection
  2. Antibiotic Fungal
  3. Siccanin

Siccanin 是一种琥珀酸脱氢酶 (SDH) 抑制剂 (IC50=0.9 μM),具有物种选择性活性。 Siccanin 也是一种抗病原真菌的抗生素。

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Siccanin Chemical Structure

Siccanin Chemical Structure

CAS No. : 22733-60-4

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  • 生物活性

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生物活性

Siccanin is a succinate dehydrogenase (SDH) inhibitor (IC50=0.9 μM) with species-selective activity. Siccanin also is a antibiotic against pathogenic fungi[1].

IC50 & Target

Succinate Dehydrogenase Inhibitor

体外研究
(In Vitro)

Siccanin (10 μg/mL) 具有物种选择性,Siccanin 抑制铜绿假单胞菌和恶臭假单胞菌的细菌 SDH,但不抑制大肠杆菌和谷氨酸棒杆菌的 SDH;Siccanin 抑制啮齿动物 SDH 但不抑制猪 SDH[1]
具体而言,Siccanin 抑制铜绿假单胞菌(残留活性 13%)和恶臭假单胞菌(>1%)膜以及小鼠(>7%)和大鼠(19%)肝线粒体的 SDH,但不抑制大肠杆菌的 SDH (77%) 和谷氨酸棒杆菌 (97%) 膜和猪心脏线粒体 (106%)[1]
Siccanin (3 μg/mL) 竞争性抑制须癣毛癣菌的生长 (IC50=0.3 μg/mL)[1]

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

342.47

Formula

C22H30O3

CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

纯度 & 产品资料
参考文献

Siccanin 相关分类

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  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Siccanin
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HY-106371
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