2. Apoptosis
  3. Apoptosis
  4. SLC7A11-IN-1

SLC7A11-IN-1 是一种有效的SLC7A11 抑制剂。SLC7A11-IN-1 显示出抗增殖活性。SLC7A11-IN-1 抑制细胞侵袭和转移。SLC7A11-IN-1 诱导细胞凋亡 (Apoptosis) 和细胞周期停滞在 S 期。SLC7A11-IN-1 具有抗肿瘤活性。

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SLC7A11-IN-1

SLC7A11-IN-1 Chemical Structure

CAS No. : 3049302-90-8

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1 mg ￥3480
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SLC7A11-IN-1 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

SLC7A11-IN-1 is a potent solute carrier family 7 member 11 (SLC7A11, xCT) inhibitor. SLC7A11-IN-1 shows antiproliferative activity. SLC7A11-IN-1 inhibits cell invasion and metastasis. SLC7A11-IN-1 induces Apoptosis and cell cycle arrest at S-phase. SLC7A11-IN-1 shows anti-tumor activity[1].

IC50 & Target

SLC7A11[1]
体外研究
(In Vitro)

SLC7A11-IN-1 (compound 2; 0-100 µM; 72 h) 显示出抗增殖活性，对于 HCT-116, MDA-MB-231, MCF-7, HepG2, LO2 细胞的 IC50 值分别为 0.03、0.11、0.18、0.17、0.27 µM[1]。
SLC7A11-IN-1 (0.5 µM; 24 h) 抑制 HCT-116 细胞的侵袭和转移[1]。
SLC7A11-IN-1 (0.5 µM; 24 h) 诱导细胞凋亡和细胞周期停滞在 S 期[1]。
SLC7A11-IN-1明显降低细胞内 GSH 含量，显着增强活性氧 (ROS) 的表达[1]。
SLC7A11-IN-1 (1 µM; 15 h) 显著诱导 HCT-116 细胞的 DNA 损伤和相关蛋白表达[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

SLC7A11-IN-1 相关抗体:

Cell Cycle Analysis[1]

Cell Line: HCT-116 cells
Concentration: 0.5 µM
Incubation Time: 24 h
Result: Induced cell apoptosis and cell cycle arrest at S-phase with the S-phase proportion of 55.79%.

Western Blot Analysis[1]

Cell Line: HCT-116 cells
Concentration: 1 µM
Incubation Time: 15 h
Result: Increased the expression of p53, Bax, p-Akt, VEGFA and HIF1-α proteins, decreased the expression of Bcl-2, xCT protein level.
体内研究
(In Vivo)

SLC7A11-IN-1 (2 mg/kg;尾静脉注射; 每三天一次，连续3次) 抑制小鼠肿瘤的生长[1]

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: male BALB/c mice (CT26 tumor models)[1]
Dosage: 2 mg/kg
Administration: I.v.; once every three days, for consecutive 3 times
Result: Suppressed the growth of tumor by 60.7%.
分子量

664.35

Formula

C13H17Cl2F3N4O5PtS
CAS 号
性状

固体

颜色

White to off-white

运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
纯度 & 产品资料
参考文献

SLC7A11-IN-1 相关分类

  • 摩尔计算器

  • 稀释计算器

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SLC7A11-IN-13049302-90-8ApoptosisHCT-116 cellsantiproliferativeinvasionmetastasiGSHROSapoptosisanti-tumorInhibitorinhibitorinhibit

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