1. PROTAC Vitamin D Related/Nuclear Receptor
  2. SNIPERs Estrogen Receptor/ERR
  3. SNIPER(ER)-87

SNIPER(ER)-87 由凋亡蛋白 (IAP) 配体 LCL161 衍生物的抑制剂组成,该抑制剂通过 PEG 接头与雌激素受体 α (ERα) 配体 4-Hydroxytamoxifen 缀合,并有效降解 ERα 蛋白 (IC50=0.097 μM)。SNIPER(ER)-87 在细胞中优先招募 XIAPERα,而 XIAP 是负责 SNIPER(ER)-87 诱导的 ERα 降解的主要 E3 泛素连接酶。

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SNIPER(ER)-87 Chemical Structure

SNIPER(ER)-87 Chemical Structure

CAS No. : 2222354-91-6

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规格 价格 是否有货 数量
5 mg ¥9310
3 - 4 周
10 mg   询价  
50 mg   询价  

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Customer Review

查看 Estrogen Receptor/ERR 亚型特异性产品:

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

SNIPER(ER)-87 consists of an inhibitor of apoptosis protein (IAP) ligand LCL161 derivative that is conjugated to the estrogen receptor α (ERα) ligand 4-hydroxytamoxifen by a PEG linker, and efficiently degrades the ERα protein (IC50=0.097 μM). SNIPER(ER)-87 preferentially recruits XIAP to ERα in the cells, and XIAP is the primary E3 ubiquitin ligase responsible for the SNIPER(ER)-87-induced ERα degradation[1][2].

体外研究
(In Vitro)

SNIPER(ER)-87 (0.1-1000 nM; 72 hours) efficiently inhibits the ERα-dependent transcriptional activation by β-estradiol and suppresses the growth of ERα-positive breast tumor cells with IC50s of 15.6 nM in MCF-7 and 9.6 nM in T47D cells[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究
(In Vivo)

SNIPER(ER)-87 (30 mg/kg, i.p., every 24 h for 14 days) inhibits the growth of MCF-7 orthotopic breast tumor xenografts in 6-week-old female BALB/c nude mice[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

分子量

1044.30

Formula

C59H73N5O10S

CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

纯度 & 产品资料
参考文献
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  • 稀释计算器

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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产品名称:
SNIPER(ER)-87
目录号:
HY-129619
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