2. GPCR/G Protein Neuronal Signaling Apoptosis Autophagy
  3. Neuropeptide Y Receptor Apoptosis Ferroptosis Autophagy
  4. Spexin TFA

Spexin TFA  (Synonyms: Neuropeptide Q TFA)

目录号: HY-P1723A
产品使用指南 技术支持

Spexin (Neuropeptide Q) TFA 是甘丙肽受体 GAL2 和 GAL3 的选择性激动剂，是具有神经递质/神经调节因子和内分泌因子作用的保守肽。Spexin TFA 可通过中枢和外周双重作用发挥功能。Spexin TFA 上调 Beclin 1 抑制过度自噬 (autophagy) 诱导的铁死亡 (ferroptosis)，减少脂肪细胞对长链脂肪酸的摄取，并通过增加脂质氧化调节能量代谢 (如降低啮齿类动物的呼吸交换比)。Spexin TFA 可改善 Doxorubicin hydrochloride (HY-15142) 诱导心脏毒性的心脏功能，保护线粒体膜电位，减少铁积累和脂质过氧化。Spexin TFA 可用于肥胖及其相关代谢紊乱、心血管疾病 (如心肌保护) 和肿瘤化疗副作用的研究。

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Spexin TFA Chemical Structure

Spexin TFA Chemical Structure

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Spexin TFA 的其他形式现货产品:

Customer Review

Other Forms of Spexin TFA:

Spexin TFA 相关抗体

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MCE 顾客使用本产品发表的 1 篇科研文献

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NPY Y1 receptor NPY Y2 receptor NPY Y4 receptor NPY Y5 receptor

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Spexin (Neuropeptide Q) TFA is a selective agonist of galanin receptors GAL2 and GAL3, and is a conserved peptide that functions as a neurotransmitter/neuromodulator and endocrine factor. Spexin TFA can function through both central and peripheral actions. Spexin TFA upregulates Beclin 1 to inhibit ferroptosis induced by excessive autophagy, reduces the uptake of long-chain fatty acids by adipocytes, and regulates energy metabolism by increasing lipid oxidation (e.g., reducing the respiratory exchange ratio in rodents). Spexin TFA improves cardiac function in the Doxorubicin hydrochloride (HY-15142)-induced cardiotoxicity model, protects mitochondrial membrane potential, and reduces iron accumulation and lipid peroxidation. Spexin TFA can be used to study obesity and its related metabolic disorders, cardiovascular diseases (e.g., cardioprotection), and side effects of tumor chemotherapy[1][2][3].

IC50 & Target

GAL2

 

GAL3

 

体外研究
(In Vitro)

Spexin TFA (1 μM；24 h) 增加 Doxorubicin (HY-15142A) 处理的新生大鼠心肌细胞 (NRCs) 活力并减少凋亡，逆转线粒体膜电位丢失并上调 GPX4/SLC7A11[2]。
Spexin TFA (20 ng/mL；2 h) 抑制分离的小鼠脂肪细胞长链脂肪酸 (LCFA) 摄取[3]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Spexin TFA 相关抗体:

Cell Viability Assay[2]

Cell Line: Neonatal rat cardiomyocytes (NRCs)
Concentration: 1 μM
Incubation Time: 24 h; with or without 0.5 μM Doxorubicin
Result: Showed a 35% increase in viability compared to Doxorubicin-treated controls, with reduced LDH release.
体内研究
(In Vivo)

Spexin (50 μg/kg；腹腔注射；每日一次；4 周) TFA 改善 Doxorubicin (5 mg/kg/周；4 周；腹腔注射) 诱导的小鼠心脏毒性模型的心脏功能，降低氧化应激[2]。
Spexin (35 μg/kg/天；皮下注射；19 天) TFA 减少雄性 Sprague-Dawley 大鼠的食物摄入量和体重增加[3]。
Spexin TFA (25 μg/kg/天；腹腔注射；10 天) 可显著降小鼠低夜间呼吸交换率 (RER)，并增加运动能力[3]。
在雌性大鼠的条件性味觉厌恶测试中，Spexin (70 μg/kg/天；腹腔注射；单剂量) TFA 未引起厌恶效应[3]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: C57BL/6 male mice (8 weeks old, 20-25 g) with Doxorubicin-induced cardiotoxicity model[2]
Dosage: 50 μg/kg Spexin
Administration: Intraperitoneal injection (i.p.), daily for 4 weeks, starting 24 h after Doxorubicin hydrochloride injection (5 mg/kg/weeks, i.p., 4 weeks; with injectionson days 0, 7, 14 and 28)
Result: Cardiac Function: Echocardiography showed increased ejection fraction (EF) from 45 ± 5% to 58 ± 4% and fractional shortening (FS) from 22 ± 3% to 30 ± 3% in Spexin-treated group compared to doxorubicin control.
Oxidative Stress: Cardiac tissue showed reduced MDA levels (2.5 ± 0.3 nmol/mg protein vs. 3.8 ± 0.4 nmol/mg protein in control) and increased SOD activity (120 ± 10 U/mg protein vs. 90 ± 8 U/mg protein in control).
Histology: H&E staining revealed less myocardial damage and fibrosis in Spexin-treated hearts.
分子量

1619.88 (free base)

Formula

C74H114N20O19S.xC2HF3O2
Sequence Shortening

NWTPQAMLYLKGAQ-NH2
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Spexin TFA 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SpexinNeuropeptide QNeuropeptide Y ReceptorApoptosisFerroptosisAutophagyNPY receptor Inhibitorinhibitorinhibit

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