2. Cell Cycle/DNA Damage Epigenetics
  3. Sirtuin
  4. SRT3657

SRT3657 是一种可透过血脑屏障的 SIRT1 激活剂，具有神经保护作用。

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SRT3657 Chemical Structure

SRT3657 Chemical Structure

CAS No. : 1383551-17-4

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SRT3657 相关抗体

Top Publications Citing Use of Products

查看 Sirtuin 亚型特异性产品:

查看所有亚型
Sirtuin SIRT1 SIRT2 SIRT3 SIRT6 SIRT5 SIRT7

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

SRT3657 is a brain-permeable activator of SIRT1, with neuroprotective effect[1].

IC50 & Target

SIRT1[1]
体内研究
(In Vivo)

SRT3657 (30 mg/kg; i.g.; daily; for 6 weeks) activates SIRT1 in CK-p25 mice[1].
SRT3657 treatment prevents synaptic and neuronal loss and effectively rescues against neurodegeneration-driven memory impairments[1].
SRT3657 recapitulates the neuroprotective potential of caloric restriction (CR)[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Adult double-transgenic CK-p25 mice (3-month-old)[1]
Dosage: 30 mg/kg
Administration: Oral gavage, daily, for 6 weeks
Result: Significantly upregulated the activity of SIRT1 in hippocampal extracts of CK-p25 animals.
分子量

774.97

Formula

C40H54N8O6S
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

SRT3657 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SRT36571383551-17-4SRT 3657SRT-3657SirtuinSIRT1neuroprotectivecaloricrestrictionsynapticneuronallossneurodegenerationmemoryimpairmentsInhibitorinhibitorinhibit

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目录号：
HY-136094
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