Syk Inhibitor II dihydrochloride 

Syk Inhibitor II dihydrochloride is a potent, high selective and ATP-competitive Syk inhibitor with an IC₅₀ of 41 nM. Syk Inhibitor II dihydrochloride inhibits 5-HT release from RBL-cells with an IC₅₀ of 460 nM. Syk Inhibitor II dihydrochloride shows less potent against other kinases and has anti-allergic effect^[1].

Syk Inhibitor II (compound 9a) dihydrochloride 对 PKCε、PKCβ2、ZAP-70、Btk 和 Itk 的作用较弱，IC₅₀ 值分别为 5.1 µM、11 µM、11.2 µM、15.5 µM 和 22.6 µM^[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Syk Inhibitor II (Compound 9a; 10-100 mg/kg) dihydrochloride 在抗原攻击前 30 分钟皮下给药，以剂量依赖方式抑制过敏反应，ID₅₀ 值为13.2 mg/kg^[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

413.23

C₁₄H₁₇Cl₂F₃N₆O

227449-73-2

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Hiroyuki Hisamichi, et al. Synthetic studies on novel Syk inhibitors. Part 1: Synthesis and structure-activity relationships of pyrimidine-5-carboxamide derivatives. Bioorg Med Chem. 2005 Aug 15;13(16):4936-51.  [Content Brief]