2. Antibody-drug Conjugate/ADC Related
  3. ADC Linker
  4. t-Boc-N-amido-PEG4-Val-Cit

t-Boc-N-amido-PEG4-Val-Cit 是一种可被蛋白酶切割的 ADC 连接子，具有 Boc 保护的胺、亲水性 PEG 间隔物和 Val-Cit 二肽。Val-Cit 二肽可被细胞蛋白酶切割，并具有可与胺发生偶联反应形成酰胺的游离羧酸。可在酸性条件下去除 Boc 以显示游离的一级胺，可用于各种反应，例如偶联或还原胺化。

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t-Boc-N-amido-PEG4-Val-Cit Chemical Structure

t-Boc-N-amido-PEG4-Val-Cit Chemical Structure

CAS No. : 2231240-82-5

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t-Boc-N-amido-PEG4-Val-Cit 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

生物活性

t-Boc-N-amido-PEG4-Val-Cit is a protease-cleavable ADC linker featuring a Boc-protected amine, a hydrophilic PEG spacer, and a Val-Cit dipeptide. The Val-Cit dipeptide is cleavable by cell proteases and features a carboxylic acid which is free for coupling reactions with amines to form amides. The Boc can be removed under acidic conditions to reveal a free primary amine, which may be used in a variety of reactions such as coupling or reductive amination.

分子量

621.72

Formula

C27H51N5O11
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料

t-Boc-N-amido-PEG4-Val-Cit 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

t-Boc-N-amido-PEG4-Val-Cit2231240-82-5ADC LinkerAntibody-drug conjugates linkerInhibitorinhibitorinhibit

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