2. Vitamin D Related/Nuclear Receptor Immunology/Inflammation
  3. VD/VDR Interleukin Related
  4. Tacalcitol monohydrate

Tacalcitol monohydrate  (Synonyms: 1,24(R)-Dihydroxyvitamin D3 monohydrate)

目录号: HY-32338 纯度: 99.85%
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Tacalcitol monohydrate (1,24(R)-Dihydroxyvitamin D3; 1.alpha.,24R-Dihydroxyvitamin D3 monohydrate) 能通过调节钙离子促进正常骨生长。Tacalcitol monohydrate 可抑制癌细胞增殖和迁移。Tacalcitol monohydrate 可用于炎症、癌症、皮肤病的研究。

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Tacalcitol monohydrate

Tacalcitol monohydrate Chemical Structure

CAS No. : 93129-94-3

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规格 价格 是否有货 数量
1 mg ￥1400
In-stock
5 mg ￥4300
In-stock
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50 mg   询价  
100 mg   询价  

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Other Forms of Tacalcitol monohydrate:

Tacalcitol monohydrate 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Tacalcitol monohydrate (1,24(R)-Dihydroxyvitamin D3; 1.alpha.,24R-Dihydroxyvitamin D3 monohydrate) can promote normal bone growth by regulating calcium ions. Tacalcitol monohydrate inhibits cancer cell proliferation and migration. Tacalcitol monohydrate can be used in the research of inflammation, cancer, and skin diseases[1][2][3][4][5].

体外研究
(In Vitro)

Tacalcitol (0.1-100 μM，24 小时) monohydrate 以剂量依赖性方式抑制鼻息肉培养物中 IL-6 和 IL-8 的合成[1]。
Tacalcitol (10-4-1 μM，48 小时 或 1 周) monohydrate 诱导正常人角质形成细胞分化，抑制正常和银屑病人角质形成细胞的生长[2][3]。
Tacalcitol (0-1 μM，48 小时) monohydrate 抑制正常人角质形成细胞的 DNA 合成[3]。
Tacalcitol (0.001-10 μM，6 天) monohydrate 显著抑制人胶质母细胞瘤增殖[4]。
Tacalcitol (10 μM，41 小时) monohydrate 可抑制人胶质母细胞瘤迁移[4]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Tacalcitol monohydrate 相关抗体:

Cell Proliferation Assay[3]

Cell Line: normal human keratinocytes
Concentration: 10-10, 10-9, 10-8, 10-7, 10-6 M
Incubation Time: one week
Result: Significantly inhibited the growth of human keratinocytes at concentrations higher than 10-8 M.
The growth of keratinocytes was 65% inhibited by 10-8 M and 90% inhibited by 10-7 M

Cell Viability Assay[4]

Cell Line: T98G cells
Concentration: 0.001, 0.01, 0.1, 1, 10 μM
Incubation Time: 6 days
Result: Treatment for 6 days resulted in a significant, dose-dependent inhibitory effect on cell viability/growth.
Treatment of cells for less than 6 days did not influence cell viability/growth.

Cell Migration Assay [4]

Cell Line: T98G cells
Concentration: 10 μM
Incubation Time: 41 h (pre-treated for 24 h, then cells were scraped and monitore for 17 h)
Result: Reduced the migration rate.
After 17 hr, the wound closure of control cells was about 60%, while treated cells had a wound closure of about 35-45%.
体内研究
(In Vivo)

Tacalcitol (0.2-20 μg/g; 涂抹于皮肤炎症区域) monohydrate 软膏可缓解无毛小鼠被 TPA 诱导的皮肤炎症，改善表皮分化[5]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Female SKH1 (hr/hr) hairless mice (7-8 weeks old, Phorbol 12-myristate 13-acetate (HY-18739) (12-Otetradecanoylphorbol 13-acetate (TPA)) was topically applied to 6 cm2 area of the dorsal skin to induce cutaneous inflammation)[5]
Dosage: 0.2, 2, 20 μg/g
Administration: Applied to the cutaneous inflammation area
Result: Significantly inhibited TPA-induced cutaneous inflammation, histopathologically.
The effect of 20 μg/g on cutaneous inflammation was much stronger than that of 2 μg/g.
20 μg/g also significantly inhibited TPA-induced myeloperoxidase (MPO) activity.
The effect on epidermal proliferation was significant at the doses of 2 μg/g and 20 μg/g, and that on epidermal differentiation was significant at the doses of 0.2 μg/g or more.
Clinical Trial
分子量

434.65

Formula

C27H46O4
CAS 号
性状

固体

颜色

White to off-white

中文名称

他卡西妥一水物；一水他卡西醇
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

4°C, protect from light, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)

纯度 & 产品资料
参考文献

Tacalcitol monohydrate 相关分类

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The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Tacalcitol93129-94-31,24(R)-Dihydroxyvitamin D3他卡西妥一水物一水他卡西醇VD/VDRInterleukin RelatedVitamin DVitamin D receptorILInhibitorinhibitorinhibit

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