1. Immunology/Inflammation
  2. CD3
  3. Talquetamab

Talquetamab  (Synonyms: JNJ-64407564)

目录号: HY-P99394 纯度: 98.52%
COA

Talquetamab(JNJ-64407564)是一种人源化的双特异性抗体,可与 GPRC5D (G 蛋白偶联受体家族C5组成员 D) 和 CD3 结合,通过T 细胞的募集和活化诱导 T 细胞介导的杀死表达 GPRC5 的 MM 细胞。Talquetamab(JNJ-64407564)具有抗肿瘤活性。

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Talquetamab Chemical Structure

Talquetamab Chemical Structure

CAS No. : 2226212-40-2

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Talquetamab (JNJ-64407564) is a humanized bispecific antibody that binds to GPRC5D (member of G protein-coupled receptor family C5 group D) and CD3 to induce T cell-mediated killing of GPRC5D-expressing MM cells through T cell recruitment and activation. Talquetamab (JNJ-64407564) has antitumor activity[1][2].

体外研究
(In Vitro)

Talquetamab (0.00128-4.0 μg/mL, 48 h) 有效诱导多发性骨髓瘤细胞裂解,并导致活化的 CD4+ 和CD8+ T 细胞比例显著增加,以及颗粒酶 B 和炎症细胞因子如 IL-6、IL-8 和 TNF-α 水平的剂量依赖性增加[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究
(In Vivo)

Talquetamab (JNJ-64407564) (0.1-50 µg, s.c. or i.v.)在 H929 和 MM 小鼠模型中有明显的抗肿瘤活性[2]

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Female NSG mice with H929 cells[2]
Dosage: 0.1-10 µg (0.005 mg/kg)
Administration: Subcutaneous injection; on days 0, 3, 5, 7, and 10
Result: Completely blocked tumor formation at 1 μg and 10 μg doses.
Animal Model: Female NSG mice with human MM cells[2]
Dosage: 0.1-50 µg (0.005 mg/kg)
Administration: Intravenous injection; on days 15, 18, 22, 24, 29, 32, and 36
Result: Significantly inhibited tumor growth by 65% at the dose of 1μg and showed significant anti-tumor activity at 10 and 50 μg with complete tumor regression.
Clinical Trial
CAS 号
性状

液体

颜色

Colorless to light yellow

运输条件

Shipping with dry ice.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

纯度 & 产品资料

纯度: 98.52%

参考文献

Talquetamab 相关分类

  • 摩尔计算器

  • 稀释计算器

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Talquetamab
目录号:
HY-P99394
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