2. Epigenetics Apoptosis
  3. MicroRNA Apoptosis
  4. Targaprimir-96

Targaprimir-96 是 microRNA-96 (miR-96) 加工的有效抑制剂。Targaprimir-96 选择性地调节癌细胞中 miR-96 的产生并触发凋亡 (apoptosis)。Targaprimir-96 高亲和力的与 primary miR-96 (pri-miR-96) 结合。Targaprimir-96 直接与乳腺癌细胞中的 pri-miR-96 结合，并不影响健康乳腺细胞。

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Targaprimir-96 Chemical Structure

Targaprimir-96 Chemical Structure

CAS No. : 1655508-14-7

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Targaprimir-96 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Targaprimir-96 is a potent inhibitor of microRNA-96 (miR-96) processing. Targaprimir-96 selectively modulates miR-96 production in cancer cells and triggers apoptosis. Targaprimir-96 binds primary miR-96 (pri-miR-96) with low nanomolar affinity. Targaprimir-96 directly engages pri-miR-96 in breast cancer cells and is ineffective on healthy breast cells[1].

体外研究
(In Vitro)

Targaprimir-96 shows a dose-response in MDA-MB-231 triple negative breast cancer cells with an IC50 of ~50 nM by assessing the reduction of mature miR-96 levels. Targaprimir-96 (50 nM) boosts the amount of the pri-miRNA and decreases the levels of the pre-miRNA and mature miRNA in a dose-dependent manner[1].
Targaprimir-96 (50 nM; 48 hours) increases FOXO1 levels and triggers apoptosis in breast cancer cell line 4175[1].
Targaprimir-96 binds RNA3 (contains both the Drosha site and the adjacent 1×1 nt GG internal loop) with a Kd of 85 nM. Targaprimir-96 binds RNA1, RNA2, RNA4, and RNA5 with Kd values of 1.2, 0.9, 1.2, and 1.5 μM, respectively. Thus, Targaprimir-96 is highly RNA-selective and recognizes both the 1×1 nt GG and 1×1 nt UU loops to provide high affinity, effectively discriminating against a variety of related targets[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Targaprimir-96 相关抗体:
体内研究
(In Vivo)

Targaprimir-96 (10 mg/kg; i.p.; every other day for 21 days) inhibits tumor growth in a mouse model of triple-negative breast cancer (TNBC)[1].
The amount of Targaprimir-96 (2 or 7 mg/kg; i.p.) in plasma peaks is ~4 h in FVB/n mice. Importantly, even 48 hours postinjection, the concentration of Targaprimir-96 remaining in plasma is much greater than the 50 nM cellular concentration that triggered apoptosis: 1.6 μM for the 2 mg/kg dosage and 1.9 μM for the 7 mg/kg dosage[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Female NOD/Scid mice (Mouse Model of TNBC)[1]
Dosage: 10 mg/kg
Administration: i.p.; every other day for 21 days
Result: Decreased levels of mature miR-96 by ∼50% and increased levels of pri-miR-96, with a concomitant increase of FOXO1. No toxicity was observed.
分子量

1391.75

Formula

C77H102N18O7
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Targaprimir-96 相关分类

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  • 稀释计算器

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  • Do most proteins show cross-species activity?

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Keywords:

Targaprimir-961655508-14-7Targaprimir96Targaprimir 96MicroRNAApoptosismiRNAtriplenegativebreastcancercellsMDA-MB-231microRNAtumorgrowthapoptosisInhibitorinhibitorinhibit

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