2. Membrane Transporter/Ion Channel Neuronal Signaling
  3. nAChR
  4. TC-2559 difumarate

TC-2559 difumarate 是 CNS 选择性，具有口服活性的烟碱乙酰胆碱受体 (nAChR) α4β2 亚型的部分激动剂。TC-2559 difumarate 对 α2β4、α4β4 和 α3β4 受体表现出选择性，EC50在 10-30 µM 范围内。

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TC-2559 difumarate Chemical Structure

TC-2559 difumarate Chemical Structure

CAS No. : 2454492-41-0

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规格 价格 是否有货 数量
50 mg ￥23306
3 - 4 周
100 mg   询价  
200 mg   询价  

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Other Forms of TC-2559 difumarate:

TC-2559 difumarate 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

TC-2559 idifumarate is a CNS-selective, orally active α4β2 subtype of nicotinic acetylcholine receptor (nAChR) partial agonist (EC50=0.18 μM). TC-2559 difumarate shows selectivity for α4β2 over α2β4, α4β4 and α3β4 receptors, with EC50s in the range of 10-30 µM. Antinociceptive effect[1][2].

体内研究
(In Vivo)

TC-2559 difumarate (1-10 mg/kg; i.p.) dose dependently reduces acute formalin-induced biphasic nociceptive responses in mice[2].
TC-2559 difumarate (0.3-3 mg/kg; i.p.) dose dependently inhibits CCI-induced neuropathic pain in rats[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Adult male mice (body weight 15-30 g) (formalin test)[2]
Dosage: 1, 3, 10 mg/kg
Administration: I.p.
Result: Dose dependently reduced both early and late phases of formalin induced nociceptive behavioral responses.
Animal Model: Adult male SD rats (body weight 200-220 g) (chronic constriction injury (CCI))[2]
Dosage: 0.3, 1, 3 mg/kg
Administration: I.p.
Result: Significantly reversed CCI induced the paw withdrawal threshold decreases.
分子量

438.43

Formula

C20H26N2O9
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

TC-2559 difumarate 相关分类

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

TC-2559 difumarate2454492-41-0nAChRNicotinic acetylcholine receptorsnociceptiveresponsespainCNS-selectiveoralInhibitorinhibitorinhibit

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