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  3. TC-G 24

TC-G 24 

目录号: HY-107529
产品使用指南

TC-G 24 (Compound 24) 是一种有效的、选择性的糖原合成酶激酶 3β (GSK-3β) 抑制剂,IC50 值为 17.1 nM。TC-G 24 能透过血脑屏障 (BBB),可以用于研究许多疾病,如 2 型糖尿病、中风、阿尔茨海默病和其他相关疾病。

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TC-G 24 Chemical Structure

TC-G 24 Chemical Structure

CAS No. : 1257256-44-2

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查看 GSK-3 亚型特异性产品:

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

TC-G 24 (Compound 24) is a potent, selective glycogen synthase kinase-3β (GSK-3β) inhibitor with an IC50 of 17.1 nM. TC-G 24 can cross the BBB and can be used for studying many diseases such as type 2 diabetes mellitus, stroke, Alzheimer, and other related diseases[1].

IC50 & Target

GSK-3β

17.1 nM (IC50)

体外研究
(In Vitro)

TC-G 24 (Compound 24) binds to the ATP binding site of GSK-3β[1].
TC-G 24 (1 µM, 4 h) blocks the FBW7α-mediated degradation of TPP1 in human embryonic kidney (HEK) 293T cells[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Western Blot Analysis[2]

Cell Line: 293T cells
Concentration: 1 μM
Incubation Time: 4 h
Result: Blocked the FBW7α-mediated degradation of TPP1
体内研究
(In Vivo)

TC-G 24 (Compound 24) (0-15 mg/kg; i.p.; once) significantly raises liver glycogen content in a dose-dependent manner without obvious toxicity and can cross the BBB[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Six-week-old male C57BL/6N mice with weights averaging 22 g[1]
Dosage: 1, 5, and 15 mg/kg
Administration: Intraperitoneal injection, once
Result: Significantly raised liver glycogen content in a dose-dependent manner without obvious toxicity. Was detected in the brain at concentrations higher than in plasma for all three tested doses (38 ± 6, 113 ± 54 and 286 ± 58 ng/g brain tissue at 1, 5 and 15 mg/kg, respectively).
分子量

330.73

Formula

C15H11ClN4O3

CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

参考文献
  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2

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