2. Inhibitory Antibodies
  3. Telisotuzumab

Telisotuzumab  (Synonyms: ABT-700)

目录号: HY-P99391 纯度: 99.49%
COA

摩尔计算器

Telisotuzumab (ABT-700) 是一种人源化重组二价抗体，针对肝细胞生长因子受体（MET）的治疗性抗体，可以高亲和力结合 c-Met 并抑制 c-Met 信号传导。Telisotuzumab 具有抗肿瘤活性。

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Telisotuzumab Chemical Structure

Telisotuzumab Chemical Structure

CAS No. : 1781223-80-0

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1 mg ￥3200
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Telisotuzumab 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Telisotuzumab (ABT-700) is a human recombinant bivalent antibody, a therapeutic antibody against the hepatocyte growth factor receptor (MET) that binds c-Met with high affinity and inhibits c-Met signaling. Telisotuzumab has antitumor activity[1].

体外研究
(In Vitro)

Telisotuzumab (ABT-700) (10 μg/mL, 24 h) 可以抑制 SNU5 细胞的增殖，并导致促凋亡的 Bim 增加和抗凋亡的 Bcl-xL 减少，从而诱发细胞凋亡[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Telisotuzumab 相关抗体:
体内研究
(In Vivo)

Telisotuzumab (ABT-700) (i.p., 2.5-40 mg/kg, twice a week, 90 days) 有效拮抗构成性激活的 c-Met 和下游信号，从而抑制 Hs746T 细胞 SCID 小鼠的肿瘤生长[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: SCID mice with Hs746T cells[1]
Dosage: 2.5-40 mg/kg
Administration: i.p., twice a week, 90 days
Result: Reduced total and phosphorylated c-Met as well as phosphorylated Akt and Erk.
Complete tumor regression at doses above 10 mg/kg but no effective inhibition of tumor growth at doses below 5mg/kg.
Clinical Trial
CAS 号
性状

液体

颜色

Colorless to light yellow

运输条件

Shipping with dry ice.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料

纯度: 99.49%

COA (172 KB)

抗体抑制剂使用指南 (1152 KB)
参考文献

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Telisotuzumab1781223-80-0ABT-700ABT700ABT 700Othersbivalent antibodyMEThepatocyte growth factor receptorantitumorInhibitorinhibitorinhibit

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