2. Protein Tyrosine Kinase/RTK Apoptosis
  3. c-Met/HGFR Apoptosis
  4. Telisotuzumab (powder)

Telisotuzumab (powder)  (Synonyms: ABT-700 (powder))

目录号: HY-P99391A
产品使用指南 技术支持

Telisotuzumab (ABT-700) (powder) 是一种二价人源化 IgG1 抗 c-Met 单克隆抗体。Telisotuzumab (powder) 可结合细胞内的 c-Met，并阻断其由 HGF 或细胞表面高密度 c-Met 诱导的二聚化和活化，且不依赖于配体。Telisotuzumab (powder) 可诱导细胞凋亡 (apoptosis)。Telisotuzumab (powder) 可用于研究携带 MET 扩增的癌症，例如胃癌和肺癌。

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Telisotuzumab (powder)

Telisotuzumab (powder) Chemical Structure

CAS No. : 1781223-80-0

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Telisotuzumab (powder) 的其他形式现货产品:

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Telisotuzumab (powder) 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Telisotuzumab (ABT-700) (powder) is a bivalent humanized IgG1 anti-c-Met monoclonal antibody. Telisotuzumab (powder) binds cellular c-Met and disrupts its productive dimerization and activation induced by HGF or by the high density of c-Met on the cell surface independent of ligand. Telisotuzumab (powder) induces apoptosis. Telisotuzumab (powder) can be used for the study of cancers harboring amplified MET, such as gastric and lung cancers[1].

体外研究
(In Vitro)

Telisotuzumab (ABT-700) (10 μg/mL, 24 h) (powder) 可以抑制 SNU5 细胞的增殖，并导致促凋亡的 Bim 增加和抗凋亡的 Bcl-xL 减少，从而诱发细胞凋亡[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Telisotuzumab (powder) 相关抗体:
体内研究
(In Vivo)

Telisotuzumab (ABT-700) (i.p.，2.5-40 mg/kg，一周两次，90 天) (powder) 有效拮抗构成性激活的 c-Met 和下游信号，从而抑制 Hs746T 细胞 SCID 小鼠的肿瘤生长[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: SCID mice with Hs746T cells[1]
Dosage: 2.5-40 mg/kg
Administration: i.p., twice a week, 90 days
Result: Reduced total and phosphorylated c-Met as well as phosphorylated Akt and Erk.
Complete tumor regression at doses above 10 mg/kg but no effective inhibition of tumor growth at doses below 5mg/kg.
分子量

146.1 kDa

CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Telisotuzumab (powder) 相关分类

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  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Telisotuzumab (powder)1781223-80-0ABT-700 (powder)c-Met/HGFRApoptosisbivalent antibodyMEThepatocyte growth factor receptorantitumorInhibitorinhibitorinhibit

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