2. Immunology/Inflammation
  3. Transmembrane Glycoprotein
  4. Thrombospondin (TSP-1)-derived CD36 binding motif

Thrombospondin (TSP-1)-derived CD36 binding motif 

目录号: HY-P5322 纯度: 98.87%
COA 产品使用指南 技术支持

Thrombospondin (TSP-1)-derived CD36 binding motif 是一种具有生物活性的六肽 (hexapeptide)。Thrombospondin (TSP-1)-derived CD36 binding motif 通过与 CD36 和血管抑制素结合，干扰细胞与细胞外基质之间的相互作用，从而影响细胞粘附、迁移过程。Thrombospondin (TSP-1)-derived CD36 binding motif 抑制血小板聚集。Thrombospondin (TSP-1)-derived CD36 binding motif 对结肠癌发挥抗肿瘤作用。

MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

Custom Peptide Synthesis

Thrombospondin (TSP-1)-derived CD36 binding motif Chemical Structure

Thrombospondin (TSP-1)-derived CD36 binding motif Chemical Structure

CAS No. : 138849-26-0

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

规格 价格 是否有货 数量
1 mg ￥540
In-stock
5 mg ￥1355
In-stock
10 mg ￥1762
In-stock
50 mg   询价  
100 mg   询价  

* Please select Quantity before adding items.

Thrombospondin (TSP-1)-derived CD36 binding motif 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Thrombospondin (TSP-1)-derived CD36 binding motif is a bioactive hexapeptide. Thrombospondin (TSP-1)-derived CD36 binding motif interferes with the interaction between cells and the extracellular matrix by binding to CD36 and angiostatin, thereby affecting the cell adhesion and migration process. Thrombospondin (TSP-1)-derived CD36 binding motif inhibits platelet aggregation. Thrombospondin (TSP-1)-derived CD36 binding motif exerts an anti-tumor effect against colon cancer[1][2][3][4].

体外研究
(In Vitro)

Thrombospondin (TSP-1)-derived CD36 binding motif (200 μM) 可抑制活化血小板上血小板反应蛋白的表面表达，并部分抑制 A23187 (HY-N6687)、Epinephrine (HY-B0447B)、ADP (HY-W010918) 和Collagen 等激动剂引起的血小板聚集[1]。
Thrombospondin (TSP-1)-derived CD36 binding motif (200 μM) 可完全抑制经 Retinoic acid (HY-14649) 处理的 SK-N-SH 细胞与 TSP-1 的附着，IC50 为 80 μM[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Thrombospondin (TSP-1)-derived CD36 binding motif 相关抗体:
体内研究
(In Vivo)

Thrombospondin (TSP-1)-derived CD36 binding motif (10 mg/kg；腹腔注射；每隔一天；4 周) 在人类结肠癌小鼠模型 (雌性 BALB/c nu/nu 小鼠) 中显示出抗肿瘤作用[4]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Female BALB/c nu/nu mice (weight: 12-18 g, age: 8-10 weeks), human xenograft splenic injection model of colon cancer[4]
Dosage: 10 mg/kg (in PBS)
Administration: Intraperitoneal injection, every other day, 4 weeks
Result: Significantly reduced the primary tumor volume by 69% compared with the control group.
Improved the health score and internal disease score, with a minimum 30% improvement in both scores compared with control animals.
分子量

566.65

Formula

C20H34N6O9S2
CAS 号
性状

固体

颜色

White to off-white

Sequence

Cys-Ser-Val-Thr-Cys-Gly (Disulfide bridge: Cys1-Cys5)
Sequence Shortening

CSVTCG (Disulfide bridge: Cys1-Cys5)
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Sealed storage, away from moisture

Powder -80°C 2 years
-20°C 1 year

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

溶解性数据
细胞实验： 

H2O 中的溶解度 : 10 mg/mL (17.65 mM; 超声助溶)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 1.7648 mL 8.8238 mL 17.6476 mL
5 mM 0.3530 mL 1.7648 mL 3.5295 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

* 备注：如您选择水作为储备液，请稀释至工作液后，再用 0.22 μm 的滤膜过滤除菌后使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息：

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

只
由于实验过程有损耗，建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
您所需的储备液浓度超过该产品的实测溶解度，如有需要，请与 MCE 中国技术支持联系。
纯度 & 产品资料
参考文献

Thrombospondin (TSP-1)-derived CD36 binding motif 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)。-80°C储存时，请在6个月内使用，-20°C储存时，请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 1.7648 mL 8.8238 mL 17.6476 mL 44.1189 mL
5 mM 0.3530 mL 1.7648 mL 3.5295 mL 8.8238 mL
10 mM 0.1765 mL 0.8824 mL 1.7648 mL 4.4119 mL
15 mM 0.1177 mL 0.5883 mL 1.1765 mL 2.9413 mL

* 备注：如您选择水作为储备液，请稀释至工作液后，再用 0.22 μm 的滤膜过滤除菌后使用。

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Thrombospondin (TSP-1)-derived CD36 binding motif138849-26-0Transmembrane GlycoproteinBALB/cmiceanti-tumorcolon cancerSK-N-SHInhibitorinhibitorinhibit

您最近查看的产品:

Your information is safe with us. * Required Fields.

   产品名称：

  

* 需求量：

* 客户姓名：

 

* Email：

* 电话：

 

* 公司或机构名称：

   留言给我们：

Bulk Inquiry

Inquiry Information

产品名称：
Thrombospondin (TSP-1)-derived CD36 binding motif
目录号：
HY-P5322
需求量：

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

   产品名称：

  

* Lot #：

* 客户姓名：

 

* Email：

   电话：

 

* 部门：

* 公司或机构名称：

 

   留言给我们：

Request for HNMR Report

We have received your request and will respond to you as soon as possible.

嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z