2. Antibody-drug Conjugate/ADC Related
  3. Drug-Linker Conjugates for ADC
  4. TL033 TFA

TL033 TFA 是抗体偶联药物的一部分 (drug-linker conjugate for ADC)。TL033 TFA 包含一个 linker 和具有生物活性的小分子毒素。TL033 TFA 可与 Sacituzumab 抗体 (抗 Trop-2) 偶联，用于合成 BT001021。BT001021 对多种癌症具有抗癌活性，如乳腺癌、非小细胞肺癌 (NSCLC)、胃癌。

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TL033 TFA

TL033 TFA Chemical Structure

CAS No. : 2746343-70-2

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规格 价格 是否有货 数量
1 mg ￥3500
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Other Forms of TL033 TFA:

TL033 TFA 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

TL033 TFA is a drug-Linker conjugates for ADC. TL033 TFA contains a linker and bioactive small molecule toxins. TL033 TFA can conjugate with Sacituzumab antibody (anti Trop-2) for synthesizing BT001021. BT001021 has anti-cancer activities against various cancers, such as breast cancer, non-small cell lung cancer (NSCLC), gastric cancer[1].

体外研究
(In Vitro)

BT001021 (3 days) 对 HCC1806 细胞 (乳腺癌细胞系) 显示出杀伤作用 (EC50：13.15 nM)[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

TL033 TFA 相关抗体:
体内研究
(In Vivo)

BT001021 (静脉注射，3 mg/kg，每周两次，共 6 次) 可抑制 NCI-N87 胃癌异种移植模型小鼠的肿瘤生长，给药结束时肿瘤消退[1].
BT001021 (静脉注射，10 mg/kg 单剂量给药) 表现出明显的肿瘤组织靶向性和良好的药代动力学特性[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

1630.83 (free base)

Formula

C76H103N13O23S2.xC2HF3O2
CAS 号
性状

固体

颜色

Light yellow to yellow

运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

-20°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

纯度 & 产品资料
参考文献

TL033 TFA 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

TL0332746343-70-2TL 033TL-033Drug-Linker Conjugates for ADCInhibitorinhibitorinhibit

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产品名称：
TL033 TFA
目录号：
HY-147340A
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