2. Metabolic Enzyme/Protease
  3. Endogenous Metabolite
  4. TLQP-62 (mouse,rat)

TLQP-62 (mouse,rat) 是一种可以从蛋白 VGF 中衍生而来的分泌型 C 端肽。TLQP-62 激活 BDNF-TrkB 信号通路，诱导 TrkB 受体的急性、短暂磷酸化以及下游 CREB (Ser133) 的磷酸化。TLQP-62 在促进野生型小鼠的长期恐惧记忆形成方面表现出极佳的功效，并能逆转 VGF 杂合敲除小鼠的记忆障碍。TLQP-62 可用于研究与记忆相关的神经疾病 (如阿尔茨海默病、额颞痴呆)。

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Custom Peptide Synthesis

TLQP-62 (mouse,rat)

TLQP-62 (mouse,rat) Chemical Structure

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TLQP-62 (mouse,rat) 相关抗体

Top Publications Citing Use of Products

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

TLQP-62 (mouse,rat) is a secreted C-terminal peptide that can be derived from protein VGF. TLQP-62 activates the BDNF-TrkB signaling pathway, inducing acute, transient phosphorylation of TrkB receptor and downstream CREB (Ser133) phosphorylation. TLQP-62 demonstrates excellent efficacy in promoting long-term fear memory formationin wild-type mice and reversing memory impairment in VGF heterozygous knock-out mice. TLQP-62 can be used for the study of memory-related neurological disorders (e.g., Alzheimer’s disease, frontotemporal dementia)[1].

体外研究
(In Vitro)

TLQP-62 (10 μM, 10 min) 急性且短暂地激活 TrkB 受体磷酸化[1]。
TLQP-62 (10 μM, 30 min) 诱导 CREB 磷酸化 (Ser133) 并促进小鼠海马切片中 cofilin 的磷酸化[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

TLQP-62 (mouse,rat) 相关抗体:
体内研究
(In Vivo)

TLQP-62 (0.3 μg/侧，双侧海马注射，训练后立即一次给药) 增强小鼠的长期恐惧记忆形成[1]。
TLQP-62 (5 mg/kg，腹腔注射，训练后立即一次给药) 逆转雄性 N2F1 VGF 杂合敲除小鼠的记忆障碍[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male C57BL/6J mice (2-3 months old)[1]
Dosage: 0.3 μg/side
Administration: Bilateral hippocampal injection once immediately after training
Result: Achieved enhanced long-term fear memory formation.
Showed significant induction of CREB phosphorylation (Ser133) in the dorsal hippocampus, with a magnitude and kinetics similar to recombinant BDNF-induced CREB phosphorylation.
Appeared no significant effects on short-term memory or locomotor activity.
Animal Model: VGF germline heterozygous knock-out mouse[1]
Dosage: 5 mg/kg
Administration: i.p. once immediately after CFC training
Result: Achieved reversed memory impairment in VGF heterozygous knock-out mice.
Restored Rac1 mRNA induction in the dorsal hippocampus.
Showed no enhancement of memory performance.
分子量

7401.04

Formula

C318H499N109O97
Sequence

Thr-Leu-Gln-Pro-Pro-Ala-Ser-Ser-Arg-Arg-Arg-His-Phe-His-His-Ala-Leu-Pro-Pro-Ala-Arg-His-His-Pro-Asp-Leu-Glu-Ala-Gln-Ala-Arg-Arg-Ala-Gln-Glu-Glu-Ala-Asp-Ala-Glu-Glu-Arg-Arg-Leu-Gln-Glu-Gln-Glu-Glu-Leu-Glu-Asn-Tyr-Ile-Glu-His-Val-Leu-Leu-His-Arg-Pro
Sequence Shortening

TLQPPASSRRRHFHHALPPARHHPDLEAQARRAQEEADAEERRLQEQEELENYIEHVLLHRP
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

TLQP-62 (mouse,rat) 相关分类

  • 摩尔计算器

  • 稀释计算器

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

TLQP-62 (mouse,rat)Endogenous MetaboliteBDNFmemoryRac1TLQP-62TrkBVGFInhibitorinhibitorinhibit

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