2. Immunology/Inflammation
  3. COX
  4. Tolmetin sodium

Tolmetin sodium  (Synonyms: 托麦汀钠盐；托美丁钠盐)

目录号: HY-B1799A
产品使用指南

摩尔计算器

Tolmetin sodium 是一种具有口服活性的，有效的 COX 抑制剂，对人 COX-1 和 COX-2 的 IC50 值分别为 0.35 μM 和 0.82 μM。Tolmetin sodium 属于非甾体类物质，具有强效的抗炎活性。

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Tolmetin sodium Chemical Structure

Tolmetin sodium Chemical Structure

CAS No. : 35711-34-3

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Tolmetin sodium 的其他形式现货产品:

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Other Forms of Tolmetin sodium:

Tolmetin sodium 相关抗体

Top Publications Citing Use of Products

查看 COX 亚型特异性产品:

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COX COX-1 COX-2 COX-3

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Tolmetin sodium is an orally active and potent COX inhibitor with IC50s of 0.35 μM and 0.82 μM human COX-1 and COX-2, respectively. Tolmetin sodium is a non-steroidal anti-inflammatory drug (NSAID)[1][2].

IC50 & Target[1]

Human COX-1

0.35 μM (IC50)

Human COX-2

0.82 μM (IC50)

体外研究
(In Vitro)

Tolmetin sodium (0.25 mM) does not attenuate lipid peroxidation in rat brain homogenate. Tolmetin (0.25, 0.5, 0.75, 1 mM) shows radical scavenging properties but without superoxide anion generation in rat brain homogenat[3].
Tolmetin sodium (0.001-100 μM) shows anticancer activity againts HT-29 colon cancer cell line in a dose-dependent manner[4].
Tolmetin sodium (0-100 μM) shows no effect on osteoblast growth[5].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Tolmetin sodium 相关抗体:
体内研究
(In Vivo)

Tolmetin sodium (30,100 mg/kg; gavage; single dose or twice daily for 3 and 14 days) shows maximal ulcerogenic effect 4 h after the single dose, while potently decreases after 3 and 14 days of repeated administration in male Wistar rats weighing 180-200 g. Tolmetin causes gastric lesions in 100 mg/kg[2].
Tolmetin sodium (5 mg/kg twice a day for 5 days) pre-treatment considerably attenuates quinolinic acid (QA)-induced neurotoxicity[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

279.27

Formula

C15H14NNaO3
CAS 号
中文名称

托麦汀钠盐；托美丁钠盐
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Tolmetin sodium 相关分类

  • 摩尔计算器

  • 稀释计算器

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Tolmetin35711-34-3托麦汀钠盐托美丁钠盐COXCyclooxygenasenon-steroidalanti-inflammatoryNSAIDanticancerneurotoxicityInhibitorinhibitorinhibit

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