1. MAPK/ERK Pathway Immunology/Inflammation
  2. MNK PD-1/PD-L1
  3. Tomivosertib hydrochloride

Tomivosertib hydrochloride  (Synonyms: eFT508 hydrochloride)

目录号: HY-100022A
产品使用指南

Tomivosertib (eFT508 hydrochloride) hydrochloride 是一种有效的,高度选择性的,口服活性的 MNK1MNK2 抑制剂,IC50 值均为 1-2 nM。Tomivosertib hydrochloride 处理可降低肿瘤细胞中 eIF4E 的磷酸化水平 (位点为 Ser209,IC50=2-16 nM)。Tomivosertib hydrochloride 还显著下调 PD-L1 蛋白的丰度。

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Tomivosertib hydrochloride Chemical Structure

Tomivosertib hydrochloride Chemical Structure

CAS No. : 1849590-02-8

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Tomivosertib hydrochloride 的其他形式现货产品:

Customer Review

Other Forms of Tomivosertib hydrochloride:

    Tomivosertib hydrochloride purchased from MCE. Usage Cited in: Oncogene. 2021 Feb 9.  [Abstract]

    Protein levels of eIF4E and MCL1 in LPS141 and MESSA cells upon treatment with eFT508 (30 μM, 24 h). The result indicates a inhibition of p-4E at 30 μM.

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    • 生物活性

    • 纯度 & 产品资料

    • 参考文献

    生物活性

    Tomivosertib hydrochlorideis a potent, highly selective, and orally active MNK1 and MNK2 inhibitor, with IC50s of 1-2 nM against both isoforms. Tomivosertib hydrochloride treatment leads to a dose-dependent reduction in eIF4E phosphorylation at serine 209 (IC50=2-16 nM) in tumor cell lines[1]. Tomivosertib hydrochloride also dramatically downregulates PD-L1 protein abundance[2].

    IC50 & Target

    IC50: 1-2 nM (MNK1), 1-2 nM (MNK2)[1]

    分子量

    376.84

    Formula

    C17H21ClN6O2

    CAS 号
    运输条件

    Room temperature in continental US; may vary elsewhere.

    储存方式

    Please store the product under the recommended conditions in the Certificate of Analysis.

    纯度 & 产品资料
    参考文献

    Tomivosertib hydrochloride 相关分类

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    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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