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Toralizumab  (Synonyms: 托拉珠单抗; IDEC-131; Anti-Human CD40 ligand Recombinant Antibody)

目录号: HY-P99325 纯度: 95.00%
COA

Toralizumab (IDEC-131) 是一种针对 CD40L (CD154) 的人源化单克隆抗体 (mAb),由人 γ1 重链和人 kappa 轻链组成。Toralizumab 特异性结合 T 细胞上的人 CD40L,从而阻止 CD40 信号传导。Toralizumab 是一种免疫抑制剂,具有用于活跃的系统性红斑狼疮 (SLE) 研究的潜力。

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Toralizumab Chemical Structure

Toralizumab Chemical Structure

CAS No. : 252662-47-8

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生物活性

Toralizumab (IDEC-131) is a humanized monoclonal antibody (mAb) against CD40L (CD154) comprised of human gamma 1 heavy chains and human kappa light chains. Toralizumab binds specifically to human CD40L on T cells, thereby preventing CD40 signaling. Toralizumab, a immunosuppressive agent, has the potential for active systemic lupus erythematosus (SLE) research[1][2].

IC50 & Target[1][2]

CD40L

 

分子量

148.43 (kD)

CAS 号
性状

液体

颜色

Colorless to light yellow

中文名称

托拉珠单抗

运输条件

Shipping with dry ice.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

纯度 & 产品资料

纯度: 95.00%

参考文献

Toralizumab 相关分类

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  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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