1. Inhibitory Antibodies
  2. Tregalizumab

Tregalizumab  (Synonyms: BT-061)

目录号: HY-P99327 纯度: 98.97%
COA

Tregalizumab 是一种 人源化抗人 CD4 单克隆抗体 (IgG1 型),能在体外选择性地激活调节性 T 细胞 (Tregs) 的抑制特性。Tregalizumab 可用于自身免疫性疾病 (Treg 活性不足导致) 以及过敏的研究。

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Tregalizumab Chemical Structure

Tregalizumab Chemical Structure

CAS No. : 1207446-68-1

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Tregalizumab is a humanized anti-human CD4 monoclonal antibody (IgG1 type) that selectively activates the suppressive properties of regulatory T cells (Tregs) in vitro. Tregalizumab can be used in the research of autoimmune diseases (resulting from insufficient Treg activity) and allergies[1][2][3].

IC50 & Target
体外研究
(In Vitro)

Tregalizumab 能够激活调节性 T 细胞的抑制能力[1]
Tregalizumab 减少用破伤风类毒素刺激 (以剂量依赖性方式) 分离的 PBMC 的增殖和细胞因子分泌[1]
Tregalizumab (0-30 µg/mL; 18 h) 处理 PBMC 诱导 T 细胞的 CD4 下调[2]
Tregalizumab 主要诱导炎症部位的 CD4 下调[2]

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Viability Assay[2]

Cell Line: PBMC cells
Concentration: 0-30 µg/mL
Incubation Time: 18 h
Result: Induced CD4 down-modulation of T cells.
Clinical Trial
CAS 号
性状

液体

颜色

Colorless to light yellow

运输条件

Shipping with dry ice.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

纯度 & 产品资料

纯度: 98.97%

参考文献
  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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