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  3. Triacsin C

Triacsin C  (Synonyms: WS 1228A; FR 900190)

目录号: HY-N6707
COA 产品使用指南

Triacsin C (WS 1228A) 来自金黄色链霉菌 (Streptomyces aureofaciens) ,是一种天然细胞内长链酰基辅酶A合成酶 (ACSL) 抑制剂。Triacsin C 通过抑制 ACSL 来抑制 TAG 积聚成脂滴 (LD) 。Triacsin C 对轮状病毒复制非常有效。

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Triacsin C Chemical Structure

Triacsin C Chemical Structure

CAS No. : 76896-80-5

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Top Publications Citing Use of Products
  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Triacsin C (WS 1228A), a natural intracellular long-chain acyl-CoA synthetases (ACSL) inhibitor, is from Streptomyces aureofaciens. Triacsin C inhibits TAG accumulation into lipid droplets (LD) by suppressing ACSL activity[1]. Triacsin C is found to be highly effective against rotavirus replication[2].

IC50 & Target

IC50: 3.70 μM (CpACS1), 2.32 μM (CpACS2)[3]

体外研究
(In Vitro)

Triacsin C (0-16 μM; 41 h) inhibits parasite fatty acyl-coenzyme A synthetases, and reduces CpACS1 and CpACS2 enzymes activities with IC50s of 3.70 μM and 2.32 μM, respectively, with Ki values of 595 nM and 106 nM, respectively[3].
Triacsin C (0-16 μM; 41 h) shows anti-parasitic and inhibits Cryptosporidium parvum with an IC50 value of 136 nM[3].
Triacsin C (0, 0.25, 0.5 μM; 30 min) has no effect on parasite invasion[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究
(In Vivo)

Triacsin C (8-15 mg/kg/d; p.o.; 1 week) shows anticryptosporidial efficacy and improves Cryptosporidium parvum infection by targeting parasite fatty acyl-coenzyme A synthetases[3].
Triacsin C (10 mg/kg/d; p.o.; 2 months) exhibits anti-atherosclerotic activity in aortic atherosclerosis LDLR-/- mice[4].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Cryptosporidium-infected interleukin knockout mice[3]
Dosage: 8-15 mg/kg/d
Administration: Oral gavage; 1 week
Result: Reduced parasite oocyst production up to 88.1% with no apparent toxicity.
Animal Model: Low-density lipoprotein receptor-knockout (LDLR-/-) mice (C57BL/6 background)[4]
Dosage: 10 mg/kg/d
Administration: Oral gavage; 2 months
Result: Increased plasma TG, plasma cholesterol, plasma free fatty acid, and plasma glucose concentration.
Improved the growth of aortic atherosclerosis mice, increased the body weight of mince.
分子量

207.27

Formula

C11H17N3O

CAS 号
性状

固体

结构分类
初始来源

Streptomyces aureofaciens

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
溶解性数据
In Vitro: 

DMSO 中的溶解度 : 5 mg/mL (24.12 mM; 超声加热助溶; 吸湿的 DMSO 对产品的溶解度有显著影响,请使用新开封的 DMSO)

配制储备液
浓度 溶剂体积 质量 1 mg 5 mg 10 mg
1 mM 4.8246 mL 24.1231 mL 48.2462 mL
5 mM 0.9649 mL 4.8246 mL 9.6493 mL
查看完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80°C, 6 months; -20°C, 1 month。-80°C储存时,请在6个月内使用,-20°C储存时,请在1个月内使用。

  • 摩尔计算器

  • 稀释计算器

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量
=
浓度
×
体积
×
分子量 *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start)

C1

×
体积 (start)

V1

=
浓度 (final)

C2

×
体积 (final)

V2

动物溶解方案计算器
请输入动物实验的基本信息:

给药剂量

mg/kg

动物的平均体重

g

每只动物的给药体积

μL

动物数量

由于实验过程有损耗,建议您多配一只动物的量
计算结果
工作液所需浓度 : mg/mL
纯度 & 产品资料

纯度: 99.08%

参考文献

Triacsin C 相关分类

完整储备液配制表

* 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效
储备液的保存方式和期限:-80°C, 6 months; -20°C, 1 month。-80°C储存时,请在6个月内使用,-20°C储存时,请在1个月内使用。

可选溶剂 浓度 溶剂体积 质量 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 4.8246 mL 24.1231 mL 48.2462 mL 120.6156 mL
5 mM 0.9649 mL 4.8246 mL 9.6492 mL 24.1231 mL
10 mM 0.4825 mL 2.4123 mL 4.8246 mL 12.0616 mL
15 mM 0.3216 mL 1.6082 mL 3.2164 mL 8.0410 mL
20 mM 0.2412 mL 1.2062 mL 2.4123 mL 6.0308 mL
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Triacsin C
目录号:
HY-N6707
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