2. Apoptosis Immunology/Inflammation Metabolic Enzyme/Protease NF-κB
  3. Pyroptosis Reactive Oxygen Species (ROS) Interleukin Related Caspase
  4. Troponin-IN-1

Troponin-IN-1 是一种肌钙蛋白 (troponin) 抑制剂。Troponin-IN-1 通过减少 LDH 泄漏、细胞焦亡 (pyroptosis) 和活性氧 (ROS) 积累，保护 OGD/R 损伤的 H9c2 心肌细胞。Troponin-IN-1 在 LPS (HY-D1056) 诱导的 RAW264.7 细胞中抑制 NO 产生以及 IL-1β、TNF-α 和 IL-18 的释放。Troponin-IN-1 通过 caspase-1/GSDMD/IL-18 信号通路发挥作用。Troponin-IN-1 在 LAD 诱导的心肌缺血/再灌注 (MI/R) 雄性大鼠模型中减少心肌梗死面积。Troponin-IN-1 可用于研究心肌缺血/再灌注损伤。

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Troponin-IN-1

Troponin-IN-1 Chemical Structure

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Troponin-IN-1 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Troponin-IN-1 is a troponin inhibitor. Troponin-IN-1 protects OGD/R-injured H9c2 cardiomyocytes by reducing LDH leakage, pyroptosis and ROS accumulation. Troponin-IN-1 inhibits NO production and IL-1β/TNF-α/IL-18 release in LPS (HY-D1056)-induced RAW264.7 cells. Troponin-IN-1 acts via caspase-1/GSDMD/IL-18 pathway. Troponin-IN-1 reduces myocardial infarct size in LAD-induced myocardial ischemia/reperfusion (MI/R) male rats. Troponin-IN-1 can be used for the study of myocardial ischemia/reperfusion (MI/R) injury[1].

体外研究
(In Vitro)

Troponin-IN-1 (Compound 19) (0.1-10 μM, 24 小时) 增强 OGD/R 损伤的 H9c2 心肌细胞的活力, 减少 LDH 泄漏, 并抑制活性氧 (ROS) 积累[1]。
Troponin-IN-1 (10-50 μM) 减少 H9c2 细胞的焦亡, 维持细胞形态, 并通过抑制 caspase-1/GSDMD/IL-18 信号通路阻断细胞焦亡[1]。
Troponin-IN-1 (6.25-100 μM, 预处理 30 分钟) 抑制 LPS (HY-D1056) 诱导的 RAW264.7 细胞中的 NO 产生 (IC50 = 13.49 μM), 并减少 IL-1β, TNF-α 和 IL-18 的释放[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Troponin-IN-1 相关抗体:

ELISA Assay[1]

Cell Line: LPS (HY-D1056)-induced RAW264.7 cells
Concentration: 10, 30, 50 μM
Incubation Time: Pretreatment for 30 min
Result: Reduced IL-1β, TNF-α, IL-18 release.
体内研究
(In Vivo)

Troponin-IN-1 (Compound 19) (20-80 mg/kg，腹腔注射，每日一次，持续 7 天，末次给药于术前 1 小时) 可减少 LAD 诱导的 MI/R 雄性 Sprague-Dawley 大鼠的心肌梗死面积[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male Sprague-Dawley rats: chest opened between 3rd and 4th ribs, left anterior descending coronary artery (LAD) ligated for 45 min, then ligature loosened for 24 h reperfusion to establish myocardial ischemia/reperfusion (MI/R) model[1]
Dosage: 20, 40, 80 mg/kg
Administration: intraperitoneal injection, once daily for 7 days, last dose 1 h before surgery
Result: Reduced myocardial infarct size.
Decreased serum cTn1 level, increased serum SOD activity.
Decreased serum MDA content.
Alleviated myocardial cell necrosis and inflammatory infiltration.
Showed no significant changes in body weight.
分子量

374.47

Formula

C22H30O5
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Troponin-IN-1 相关分类

  • 摩尔计算器

  • 稀释计算器

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Troponin-IN-1PyroptosisReactive Oxygen Species (ROS)Interleukin RelatedCaspaseILBorneol derivativesCardioprotectiveMyocardial ischemia reperfusionInhibitorinhibitorinhibit

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