2. Metabolic Enzyme/Protease Apoptosis
  3. TrxR Apoptosis
  4. TrxR-IN-6

TrxR-IN-6 (compound 1d) 是 TrxR 抑制剂，可诱导活性氧 (ROS) 积累，具有抗癌活性。TrxR-IN-6 可进一步导致氧化还原系统崩溃，诱导线粒体功能障碍、内质网 (ER) 应激和 DNA 损伤。最后引起氧化应激，诱导细胞凋亡 (apoptosis)。

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TrxR-IN-6

TrxR-IN-6 Chemical Structure

CAS No. : 3032446-53-7

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TrxR-IN-6 相关抗体

Top Publications Citing Use of Products

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TrxR1

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

TrxR-IN-6 (compound 1d) is a TrxR inhibitor that induces reactive oxygen species (ROS) accumulation and has anticancer activity. TrxR-IN-6 can further lead to redox system collapse, inducing mitochondrial dysfunction, endoplasmic reticulum (ER) stress, and DNA damage. Finally, it causes oxidative stress and induces apoptosis[1].

分子量

384.18

Formula

C11H12AsCl2NOS2
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

TrxR-IN-6 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

TrxR-IN-63032446-53-7TrxRApoptosisThioredoxin ReductaseAntitumorEndoplasmic reticulum (ER) stressMitochondrial dysfunctionOrganoarsenicalsReactive oxygen speciesROSThioredoxin reductaseInhibitorinhibitorinhibit

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目录号：
HY-157158
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