2. Anti-infection NF-κB Apoptosis
  3. Antibiotic Bacterial NF-κB Apoptosis
  4. Tylvalosin

Tylvalosin  (Synonyms: 泰万菌素; Acetylisovaleryltylo​sin)

目录号: HY-128423A 纯度: ≥96.0%
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Tylvalosin (Acetylisovaleryltylo?sin) 是一种具有口服活性的，广谱大环内酯抗生素 (antibiotic>)，显示抗菌活性。Tylvalosin 是一种抗病毒试剂，可用于研究 PRRSV 感染。Tylvalosin 诱导细胞凋亡 (apoptosis)。Tylvalosin 还具有抗炎活性，缓解氧化应激，并通过抑制 NF-κB 激活来缓解急性肺损伤。

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Tylvalosin Chemical Structure

Tylvalosin Chemical Structure

CAS No. : 63409-12-1

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1 mg ￥6350
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Other Forms of Tylvalosin:

Tylvalosin 相关抗体

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  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Tylvalosin (Acetylisovaleryltylo?sin) is an orally active, broad-spectrum macrolide antibiotic with antimicrobial activity. Tylvalosin is an antiviral agent used to study PRRSV infection. Tylvalosin induces apoptosis. Tylvalosin also has anti-inflammatory activity, alleviates oxidative stress, and alleviates acute lung injury by inhibiting NF-κB activation[1][2][3].

体外研究
(In Vitro)

Tylvalosin (10 μg/mL; 0.5, 1 h) 增加猪中性粒细胞中的 Caspase-3 裂解，导致细胞凋亡期间 DNA 断裂[4]。
Tylvalosin (0.1-10 μg/mL; 0.5 h) 促进巨噬细胞对猪中性粒细胞的胞吞作用，而不改变吞噬作用[4]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Tylvalosin 相关抗体:

Apoptosis Analysis[4]

Cell Line: Porcine neutrophils
Concentration: 0.1, 1.0, or 10 µg/mL
Incubation Time: 0.5, 1 h
Result: Resulted induction of concentration- and time-dependent apoptosis in porcine monocyte-derived macrophages.
体内研究
(In Vivo)

Tylvalosin tartrate (160 mg/kg; po; 7 d) 可以减轻 PRRSV 灭活疫苗免疫过程中猪的应激状态并改善猪的健康情况[5]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: PRRSV-free commercial breed piglets[5]
Dosage: 800 mg/kg Aivlosin (20% Tylvalosin Tartrate Premix)
Administration: po; 7-14 days
Result: Attenuated the increase in total white blood cells induced by immunization at day one post-immunization (DPI) and induced an increase in monocyte counts after seven DPI.
Attenuate the reduction in the percentage of CD8+ T cells induced by PRRSV-inactivated vaccine immunization at seven DPI.
分子量

1042.25

Formula

C53H87NO19
CAS 号
性状

固体

颜色

White to off-white

中文名称

泰万菌素
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
纯度 & 产品资料

纯度: ≥96.0%

COA (202 KB)

产品使用指南 (1538 KB)
参考文献

Tylvalosin 相关分类

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Tylvalosin63409-12-1Acetylisovaleryltylo​sin泰万菌素AntibioticBacterialNF-κBApoptosisNuclear factor-κBNuclear factor-kappaBinflammatoryPRRSV infectionantiviralacute lung injuryporcine neutrophilsmacrophagesInhibitorinhibitorinhibit

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