2. Immunology/Inflammation
  3. STING IFNAR Interleukin Related
  4. UM-242

UM-242 是一种 STING 抑制剂，在表达野生型 STING 的 THP1-Dual 细胞中的 EC50 为 1.70 μM。UM-242 阻断 STING 寡聚化，抑制 diABZI 诱导的 TBK1 和 IRF3 磷酸化，从而抑制 IFNβ 和 IL6 的转录，并减少 IFNβ 分泌。UM-242 可用于研究 STING 依赖性的炎症和神经系统疾病。

MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

UM-242

UM-242 Chemical Structure

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

规格 是否有货
50 mg   询价  
100 mg   询价  
250 mg   询价  

* Please select Quantity before adding items.

Customer Review

UM-242 相关抗体

Top Publications Citing Use of Products

查看 Interleukin Related 亚型特异性产品:

查看所有亚型
IL-1 IL-2 IL-3 IL-4 IL-5 IL-6 IL-8 IL-10 IL-12 IL-13 IL-15 IL-17 IL-23 IL-7 IL-33 IL-22

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

UM-242 is a STING inhibitor, with an EC50 of 1.70 μM in THP1-Dual cells expressing wild-type STING. UM-242 blocks STING oligomerization and inhibits diABZI-induced phosphorylation of TBK1 and IRF3, thereby suppressing the transcription of IFNβ and IL6 and reducing IFNβ secretion. UM-242 can be used for the study of STING-dependent inflammatory and neurological diseases[1].

体外研究
(In Vitro)

UM-242 (0.2-5 μM，预处理 1 小时) 在 iBMDMs 中对 diABZI 诱导的 IFNβ 和 IL6 基因转录表现出强效抑制活性[1]。
UM-242 (2.5 μM，预处理 1 小时) 在原代人 CD14+ 单核细胞中显示出阻断 STING 依赖性 IFNβ 分泌的强效活性[1]。
UM-242 (5 μM，预处理 1 小时) 对 diABZI 诱导的 TBK1 和 IRF3 磷酸化表现出强效抑制活性，并在 WT BMDMs 中有效抑制 STING 寡聚化，显著阻断 STING 下游信号传导[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

UM-242 相关抗体:

Western Blot Analysis[1]

Cell Line: WT BMDMs
Concentration: 5 μM
Incubation Time: Pretreated for 1 h
Result: Showed potent inhibitory activity on diABZI-induced phosphorylation of TBK1 and IRF3.
Exhibited potent activity in inhibiting STING oligomerization in WT BMDMs.
分子量

536.45

Formula

C24H18F2N8O5
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

UM-242 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

UM-242UM242UM 242STINGIFNARInterleukin RelatedStimulator of Interferon GenesTMEM173MITAERISMPYSInterferon-α/β receptorInterferon-alpha/beta receptor ILTHP1-Dual cellsTBK1IRF3IL-6IFNβinflammatory diseasesneurological diseasesInhibitorinhibitorinhibit

您最近查看的产品:

Your information is safe with us. * Required Fields.

   产品名称：

  

* 需求量：

* 客户姓名：

 

* Email：

* 电话：

 

* 公司或机构名称：

   留言给我们：

Bulk Inquiry

Inquiry Information

产品名称：
UM-242
目录号：
HY-178047
需求量：

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

   产品名称：

  

* Lot #：

* 客户姓名：

 

* Email：

   电话：

 

* 部门：

* 公司或机构名称：

 

   留言给我们：

Request for HNMR Report

We have received your request and will respond to you as soon as possible.

嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z