1. Inhibitory Antibodies
  2. Urtoxazumab

Urtoxazumab  (Synonyms: HuVTm1.1; TMA-15)

目录号: HY-P99532

Urtoxazumab (TMA-15) 是一种抗志贺毒素 Stx2 的人源化单克隆抗体。

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Urtoxazumab Chemical Structure

Urtoxazumab Chemical Structure

CAS No. : 502496-16-4

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  • 生物活性

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生物活性

Urtoxazumab (TMA-15) is a humanizedized monoclonal antibody against Shiga toxin (Stx) 2[1].

体内研究
(In Vivo)

Urtoxazumab (TMA-15) (0.25-2.5 mg/kg;注射。一次)以时间和剂量依赖的方式改善 B2F1 感染小鼠的致死率[1]

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: 5-week-old male DBA/2J mice, STEC B2F1-infection model[1]
Dosage: 0.25, 0.5, 1.0, 2.0 and 2.5 mg/kg
Administration: Intravenous administration, 1 h before and 12, 24, and 48 h after infection
Result: Pretreatment completely protected the infected mice from death, the efficacy of the low dose (0.25 mg/kg) was partial when administered at 12 and 24 h after infection, but the efficacy of the high dose (2.5 mg/kg) was still complete. Prevented death from B2F1 infection in all 20 animals at 1.0 and 2.0 mg/kg 24 h after infection.
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储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

纯度 & 产品资料
参考文献
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  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Urtoxazumab
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HY-P99532
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