Valopicitabine (Synonyms: NM283)

目录号: HY-108060: Data Sheet 产品使用指南
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技术支持

Valopicitabine (NM283) 是一种核苷类似物，是强效抗 HCV 剂的 2'-C-甲基胞苷 (NM107) 的口服生物利用前体。NM107 竞争性抑制 NS5B 聚合酶，导致链终止。

在相同的摩尔浓度下，化合物盐形式与游离形式有相同的生物活性，但盐形式 Valopicitabine dihydrochloride 通常具有更好的水溶性和稳定性。

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Valopicitabine Chemical Structure

CAS No. : 640281-90-9

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Valopicitabine 的其他形式现货产品:

Valopicitabine dihydrochloride

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Valopicitabine dihydrochloride In-stock

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生物活性
纯度 & 产品资料
参考文献

生物活性

Valopicitabine (NM283) is a nucleoside analog and the orally bioavailable proagent of the potent anti-HCV agent 2'-C-methylcytidine (NM107). NM107competitively inhibits NS5B polymerase, causing chain termination^[1]^[2].

IC₅₀ & Target

HCV^[1]

细胞效力
(Cellular Effect)

Cell Line	Type	Value	Description	References
Huh-7	CC₅₀	> 100 μM Compound: valopicitabaine	Cytotoxicity against Huh7 cells after 24 hrs by MTS assay Cytotoxicity against Huh7 cells after 24 hrs by MTS assay	[PMID: 17521911]
Huh-7	EC₅₀	1.5 μM Compound: valopicitabaine	Antiviral activity against HCV genotype 1b in Huh7 cells assessed as inhibition of viral RNA replication after 72 hrs by ribonuclease protection assay Antiviral activity against HCV genotype 1b in Huh7 cells assessed as inhibition of viral RNA replication after 72 hrs by ribonuclease protection assay	[PMID: 17521911]
Huh-7	EC₅₀	7.45 μM Compound: valopicitabaine	Antiviral activity against HCV genotype 1b in Huh7 cells assessed as inhibition of viral RNA replication after 24 hrs by ribonuclease protection assay Antiviral activity against HCV genotype 1b in Huh7 cells assessed as inhibition of viral RNA replication after 24 hrs by ribonuclease protection assay	[PMID: 17521911]
Huh-7	EC₅₀	7.6 μM Compound: 1	Antiviral activity against HCV infected in human HuH7 cells by cell-based subgenomic replicon assay Antiviral activity against HCV infected in human HuH7 cells by cell-based subgenomic replicon assay	[PMID: 19493593]

体内研究
(In Vivo)

Valopicitabine (NM283) (100 mg/kg；口服给药；Sprague-Dawley 大鼠) 显示 C_max、AUC、t_1/2 和 t_max分别为3.624 μg/mL、8.95 μg·h/mL、0.64小时和1小时^[2]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Clinical Trial

分子量

356.37

同用名

NM283

Formula

C₁₅H₂₄N₄O₆

CAS 号

640281-90-9

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

纯度 & 产品资料

产品使用指南 (1538 KB)

参考文献

[1]. Pierra C, et al. Nm 283, an efficient prodrug of the potent anti-HCV agent 2'-C-methylcytidine. Nucleosides Nucleotides Nucleic Acids. 2005;24(5-7):767-70. [Content Brief]

[2]. Pierra C, et al. Synthesis and pharmacokinetics of valopicitabine (NM283), an efficient prodrug of the potent anti-HCV agent 2'-C-methylcytidine. J Med Chem. 2006 Nov 2;49(22):6614-20. [Content Brief]

Valopicitabine 相关分类

Infection

摩尔计算器
稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量		浓度		体积		分子量 *
	=		×		×

The dilution calculator equation

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

浓度 _(start)	×	体积 _(start)	=	浓度 _(final)	×	体积 _(final)
	×		=		×
C1		V1		C2		V2

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Valopicitabine640281-90-9NM283NM 283NM-283HCVHCV ProteaseNucleoside Antimetabolite/AnalogHepatitis C virusprodrugoralnucleosideanalogchainterminationpolymeraseInhibitorinhibitorinhibit

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MedChemExpress (MCE) 只为有资质的科研机构、医药企业基于科学研究或药证申报的用途提供医药研发服务，不为任何个人或者非科研性质的、非用于药证申报使用等其他用途提供服务。

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上海工商

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沪(浦)应急管危经许[2021]201709(QFYS)

营业执照（三证合一）

Valopicitabine (Synonyms: NM283)

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Valopicitabine (Synonyms: NM283)

Customer Review

Other Forms of Valopicitabine:

Valopicitabine 相关抗体

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生物活性

纯度 & 产品资料

参考文献

Valopicitabine 相关分类

摩尔计算器

稀释计算器

The molarity calculator equation

The dilution calculator equation

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