1. Anti-infection Metabolic Enzyme/Protease Cell Cycle/DNA Damage
  2. HCV HCV Protease Nucleoside Antimetabolite/Analog
  3. Valopicitabine

Valopicitabine  (Synonyms: NM283)

目录号: HY-108060
产品使用指南

Valopicitabine (NM283) 是一种核苷类似物,是强效抗 HCV 剂的 2'-C-甲基胞苷 (NM107) 的口服生物利用前体。NM107 竞争性抑制 NS5B 聚合酶,导致链终止。

在相同的摩尔浓度下,化合物盐形式与游离形式有相同的生物活性,但盐形式 Valopicitabine dihydrochloride 通常具有更好的水溶性和稳定性。

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Valopicitabine Chemical Structure

Valopicitabine Chemical Structure

CAS No. : 640281-90-9

1.  客户无需承担相应的运输费用。

2.  同一机构(单位)同一产品试用装仅限申领一次,同一机构(单位)一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户

规格 是否有货
50 mg   询价  
100 mg   询价  
250 mg   询价  

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Valopicitabine 的其他形式现货产品:

Customer Review

Other Forms of Valopicitabine:

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Top Publications Citing Use of Products
  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Valopicitabine (NM283) is a nucleoside analog and the orally bioavailable proagent of the potent anti-HCV agent 2'-C-methylcytidine (NM107). NM107competitively inhibits NS5B polymerase, causing chain termination[1][2].

IC50 & Target

HCV[1]

体内研究
(In Vivo)

Valopicitabine (NM283) (100 mg/kg; oral administration; Sprague-Dawley Rats) shows the Cmax, AUC, t1/2, and tmax were 3.624 μg/mL, 8.95 μg h/mL, 0.64 hours and 1 hour, respectively[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Clinical Trial
分子量

356.37

Formula

C15H24N4O6

CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.

纯度 & 产品资料
参考文献
  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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产品名称:
Valopicitabine
目录号:
HY-108060
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