2. Membrane Transporter/Ion Channel Neuronal Signaling
  3. Potassium Channel Sodium Channel Calcium Channel
  4. VU6032735

VU6032735 是一种强效且具有亚型选择性的精子特异性钾通道 3 (SLO3) 抑制剂，其 IC50 值为 165 nM (hSLO3) 和 730 nM (mSLO3)。VU6032735 还能抑制钠通道和 L 型钙通道。VU6032735 可在受精后的输卵管中维持较高的组织暴露量。VU6032735 可用于避孕的研究。

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VU6032735

VU6032735 Chemical Structure

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Customer Review

VU6032735 相关抗体

Top Publications Citing Use of Products

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N-type calcium channel L-type calcium channel P/Q-type calcium channel T-type calcium channel Calcium Channel

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

VU6032735 is a potent and subtype-selective sperm-specific potassium channel 3 (SLO3) inhibitor with IC50 values of 165 nM (hSLO3) and 730 nM (mSLO3). VU6032735 also inhibits sodium channel and L-type calcium channel VU6032735 can sustain high tissue exposure in the fertilized oviduct. VU6032735 can be used for the research of contraception[1].

IC50 & Target[1]

hSLO3

165 nM (IC50)

mSLO3

730 nM (IC50)

L-type calcium channel

 

体外研究
(In Vitro)

VU6032735 (10 μM, 1-2 h) 可显著抑制人精子的超激活运动[1]。 VU6032735 (0.01-1 μM) 可抑制 HEK293 细胞中的小鼠 SLO3-γ2 通道[1]。
VU6032735 (10 μM) 可抑制钠通道和 L 型钙通道[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

VU6032735 相关抗体:
体内研究
(In Vivo)

VU6032735 (10 mg/kg，腹腔注射) 在雌性小鼠的卵巢、输卵管和子宫中能在 24 小时内维持较高的组织暴露量[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.
分子量

525.44

Formula

C25H21F6N3O3
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

VU6032735 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

VU6032735VU 6032735VU-6032735Potassium ChannelSodium ChannelCalcium ChannelKcsANa channelsNa+ channelsCa2+ channelsCa channelsPotassium channelSodium channelL-type calcium channelContraceptionInhibitorinhibitorinhibit

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产品名称：
VU6032735
目录号：
HY-175728
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