2. PI3K/Akt/mTOR
  3. Akt
  4. Wortmannin-Rapamycin Conjugate 1

Wortmannin-Rapamycin Conjugate 1 

目录号: HY-132003
产品使用指南

摩尔计算器

Wortmannin-Rapamycin Conjugate 1 (compound 7c) 是 wortmanning -rapamycin 偶联物的呋喃开环衍生物，具有较强的抗肿瘤活性和良好的水溶性。Wortmannin-Rapamycin Conjugate 1 能抑制肿瘤中 AKT 磷酸化，可用于癌症研究。

MCE 的所有产品仅用作科学研究或药证申报，我们不为任何个人用途提供产品和服务

我们将采用定制合成服务的方式为您快速提供所需产品和技术服务

Wortmannin-Rapamycin Conjugate 1 Chemical Structure

Wortmannin-Rapamycin Conjugate 1 Chemical Structure

CAS No. : 1067892-47-0

1.  客户无需承担相应的运输费用。

2.  同一机构（单位）同一产品试用装仅限申领一次，同一机构（单位）一年内

     可免费申领三个不同产品的试用装。

3.  试用装只面向终端客户。

规格 是否有货
50 mg   询价  
100 mg   询价  
250 mg   询价  

* Please select Quantity before adding items.

Customer Review

Wortmannin-Rapamycin Conjugate 1 相关抗体

Top Publications Citing Use of Products

查看 Akt 亚型特异性产品:

查看所有亚型
Akt Akt1 Akt2 Akt3

  • 生物活性

  • 纯度 & 产品资料

  • 参考文献

生物活性

Wortmannin-Rapamycin Conjugate 1 (compound 7c) is a furan ring-opened derivative of wortmannin-rapamycin conjugate with potent antitumor activities and a fine water solubility. Wortmannin-Rapamycin Conjugate 1 can inhibit the AKT phosphorylation in the tumor and can be used for cancer research[1].

体内研究
(In Vivo)

Wortmannin-Rapamycin Conjugate 1 (3,5 mg/kg, 静脉注射, 每周一次，13 d) 对 U87MG 小鼠异种移植模型具有显著的抗肿瘤活性[1]。
Wortmannin-Rapamycin Conjugate 1 (15 mg/kg, 静脉注射, 2 h) 显著抑制 U87MG 小鼠异种移植模型肿瘤中 AKT 磷酸化[1]。
Wortmannin-Rapamycin Conjugate 1 (15 mg/kg, 静脉注射, 每周一次，20 d ) 完全抑制荷瘤小鼠 HT29 结肠肿瘤的生长，HT29 是一种对雷帕霉素或沃特曼霉素类似物不敏感的结肠肿瘤模型[1]。
Wortmannin-Rapamycin Conjugate 1 (30 mg/kg, 静脉注射, 每周一次，38 d ) 在 A498 荷瘤小鼠中与 200 μg 贝伐单抗 (HY-P9906) 联用，对较大的A498肿瘤有显著的消退作用[1]。

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: HT29 bearing nude mice[1]
Dosage: 15 mg/kg, weekly for 20 d
Administration: Intravenous injection (i.v.)
Result: Showed no significant growth in tumor volume while an equivalent physical mixture of the Rapamycin and Wortmannin derivative was poorly tolerated.
分子量

1598.99

Formula

C88H131N3O23
CAS 号
运输条件

Room temperature in continental US; may vary elsewhere.
储存方式

Please store the product under the recommended conditions in the Certificate of Analysis.
纯度 & 产品资料
参考文献

Wortmannin-Rapamycin Conjugate 1 相关分类

  • 摩尔计算器

  • 稀释计算器

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

质量   浓度   体积   分子量 *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

浓度 (start) × 体积 (start) = 浓度 (final) × 体积 (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Wortmannin-Rapamycin Conjugate 11067892-47-0AktPKBProtein kinase BantitumorAKTU87MGHT29A498BevacizumabInhibitorinhibitorinhibit

您最近查看的产品:

Your information is safe with us. * Required Fields.

   产品名称：

  

* 需求量：

* 客户姓名：

 

* Email：

* 电话：

 

* 公司或机构名称：

   留言给我们：

Bulk Inquiry

Inquiry Information

产品名称：
Wortmannin-Rapamycin Conjugate 1
目录号：
HY-132003
需求量：

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

   产品名称：

  

* Lot #：

* 客户姓名：

 

* Email：

   电话：

 

* 部门：

* 公司或机构名称：

 

   留言给我们：

Request for HNMR Report

We have received your request and will respond to you as soon as possible.

嗨！很高兴为您提供帮助！

尊敬的 MCE 客户您好，
请您选择所在区域，我们将转接对应客服为您服务！

热门区域

A

B

C

F

G

H

J

L

N

Q

S

T

X

Y

Z

热 A B C F G H J L N Q S T X Y Z